Publications

2024

Karamitopoulou, Eva; Wenning, Anna Silvia; Acharjee, Animesh; Aeschbacher, Pauline; Marinoni, Ilaria; Zlobec, Inti; Gloor, Beat; Perren, Aurel (2024). Spatial heterogeneity of immune regulators drives dynamic changes of local immune responses, affecting disease outcomes in pancreatic cancer. Clinical cancer research, 30(18), pp. 4215-4226. American Association for Cancer Research 10.1158/1078-0432.CCR-24-0368

Chen, Hung-Chang; Mueller, Nico; Stott, Katherine; Kapeni, Chrysa; Rivers, Eilidh; Sauer, Carolin M; Beke, Flavio; Walsh, Stephen J; Ashman, Nicola; O'Brien, Louise; Rafati Fard, Amir; Godsinia, Arman; Li, Changtai; Joud, Fadwa; Giger, Olivier; Zlobec, Inti; Olan, Ioana; Aitken, Sarah J; Hoare, Matthew; Mair, Richard; ... (2024). Novel immunotherapeutics against LGR5 to target multiple cancer types. EMBO molecular medicine, 16(9), pp. 2233-2261. EMBO Press 10.1038/s44321-024-00121-2

Williams, Hannah L.; Frei, Ana Leni; Koessler, Thibaud; Berger, Martin D.; Dawson, Heather; Michielin, Olivier; Zlobec, Inti (2024). The current landscape of spatial biomarkers for prediction of response to immune checkpoint inhibition. NPJ precision oncology, 8(1), p. 178. Springer Nature 10.1038/s41698-024-00671-1

Pihlmann Kristensen, Maria; Korsgaard, Ulrik; Timm, Signe; Frøstrup Hansen, Torben; Zlobec, Inti; Kjær-Frifeldt, Sanne; Hager, Henrik (2024). Immunohistochemical analysis of tumor budding in stage II colon cancer: exploring zero budding as a prognostic marker. (In Press). Virchows Archiv Springer 10.1007/s00428-024-03860-2

Baumann, Elias; Dislich, Bastian; Rumberger, Josef Lorenz; Nagtegaal, Iris D; Martinez, Maria Rodriguez; Zlobec, Inti (3 July 2024). HoVer-NeXt: A Fast Nuclei Segmentation and Classification Pipeline for Next Generation Histopathology. In: Medical Imaging with Deep Learning. Paris. 03.07.2024 - 05.07.2024.

Janowczyk, Andrew; Zlobec, Inti; Walker, Cedric; Berezowska, Sabina; Huschauer, Viola; Tinguely, Marianne; Kupferschmid, Joel; Mallet, Thomas; Merkler, Doron; Kreutzfeldt, Mario; Gasic, Radivoje; Rau, Tilman T; Mazzucchelli, Luca; Eyberg, Isgard; Cathomas, Gieri; Mertz, Kirsten D; Koelzer, Viktor H; Soldini, Davide; Jochum, Wolfram; Rössle, Matthias; ... (2024). Swiss digital pathology recommendations: results from a Delphi process conducted by the Swiss Digital Pathology Consortium of the Swiss Society of Pathology. Virchows Archiv, 485(1), pp. 13-30. Springer 10.1007/s00428-023-03712-5

Neto, Pedro C; Montezuma, Diana; Oliveira, Sara P; Oliveira, Domingos; Fraga, João; Monteiro, Ana; Monteiro, João; Ribeiro, Liliana; Gonçalves, Sofia; Reinhard, Stefan; Zlobec, Inti; Pinto, Isabel M; Cardoso, Jaime S (2024). Author Correction: An interpretable machine learning system for colorectal cancer diagnosis from pathology slides. NPJ precision oncology, 8(83) Springer Nature 10.1038/s41698-024-00581-2

Dawson, Heather; Bokhorst, John-Melle; Studer, Linda; Vieth, Michael; Oguz Erdogan, Ayse Selcen; Kus Öztürk, Sonay; Kirsch, Richard; Brockmoeller, Scarlett; Cathomas, Gieri; Buslei, Rolf; Fink, David; Roumet, Marie; Zlobec, Inti; van der Laak, Jeroen; Nagtegaal, Iris D; Lugli, Alessandro (2024). Lymph node metastases and recurrence in pT1 colorectal cancer: Prediction with the International Budding Consortium Score-A retrospective, multi-centric study. United European gastroenterology journal, 12(3), pp. 299-308. Wiley 10.1002/ueg2.12521

Pihlmann Kristensen, Maria; Korsgaard, Ulrik; Timm, Signe; Hansen, Torben Frøstrup; Zlobec, Inti; Hager, Henrik; Kjær-Frifeldt, Sanne (2024). The prognostic value of tumor budding in a thoroughly characterized stage II colon cancer population in the context of a national screening program. Human pathology, 146, pp. 15-22. Elsevier 10.1016/j.humpath.2024.02.010

Neto, Pedro C; Montezuma, Diana; Oliveira, Sara P; Oliveira, Domingos; Fraga, João; Monteiro, Ana; Monteiro, João; Ribeiro, Liliana; Gonçalves, Sofia; Reinhard, Stefan; Zlobec, Inti; Pinto, Isabel M; Cardoso, Jaime S (2024). An interpretable machine learning system for colorectal cancer diagnosis from pathology slides. NPJ precision oncology, 8(56) Springer Nature 10.1038/s41698-024-00539-4

Liu, Jonathan Tc; Chow, Sarah Sl; Colling, Richard; Downes, Michelle R; Farré, Xavier; Humphrey, Peter; Janowczyk, Andrew; Mirtti, Tuomas; Verrill, Clare; Zlobec, Inti; True, Lawrence D (2024). Engineering the future of 3D pathology. The journal of pathology: clinical research, 10(1), e347. Wiley 10.1002/cjp2.347

Brouwer, N P M; Khan, A; Bokhorst, J M; Ayatollahi, F; Hay, J; Ciompi, F; Simmer, F; Hugen, N; de Wilt, J H W; Berger, M D; Lugli, A; Zlobec, I; Edwards, J; Nagtegaal, I D (2024). The complexity of shapes; how the circularity of tumor nodules impacts prognosis in colorectal cancer. Modern pathology, 37(1), p. 100376. Elsevier 10.1016/j.modpat.2023.100376

2023

Berezowska, Sabina; Cathomas, Gieri; Grobholz, Rainer; Henkel, Maurice; Jochum, Wolfram; Koelzer, Viktor H; Kreutzfeldt, Mario; Mertz, Kirsten D; Rössle, Matthias; Soldini, Davide; Zlobec, Inti; Janowczyk, Andrew (2023). Digital image analysis and artificial intelligence in pathology diagnostics-the Swiss view. Pathologie, 44(Suppl 3), pp. 222-224. Springer 10.1007/s00292-023-01262-w

Frei, Ana Leni; Oberson, Raphaël; Baumann, Elias; Perren, Aurel; Grobholz, Rainer; Lugli, Alessandro; Dawson, Heather; Abbet, Christian; Lertxundi, Ibai; Reinhard, Stefan; Mookhoek, Aart; Feichtinger, Johann; Sarro, Rossella; Gadient, Gallus; Dommann-Scherrer, Corina; Barizzi, Jessica; Berezowska, Sabina; Glatz, Katharina; Dertinger, Susanne; Banz, Yara; ... (2023). Pathologist computer-aided diagnostic scoring of tumor cell fraction: A Swiss national study. Modern pathology, 36(12), p. 100335. Springer Nature 10.1016/j.modpat.2023.100335

Sachenkova Lundström, Oxana; Verbiest, Max; Xia, Feifei; Ziaei Jam, Helyaneh; Zlobec, Inti; Anisimova, Maria; Gymrek, Melissa (2023). WebSTR: a population-wide database of short tandem repeat variation in humans. Journal of molecular biology, 435(20), p. 168260. Elsevier 10.1016/j.jmb.2023.168260

Haddad, Tariq Sami; van den Dobbelsteen, Luuk; Öztürk, Sonay K; Geene, Robin; Nijman, Isaäc J; Verrijp, Kiek; Jamieson, Nigel B; Wood, Colin; van Vliet, Shannon; Reuvers, Luuk; Achouiti, Soumia; Rutgers, Natasja; Brouwer, Nelleke; Simmer, Femke; Zlobec, Inti; Lugli, Alessandro; Nagtegaal, Iris D (2023). Pseudobudding: ruptured glands do not represent true tumor buds. The journal of pathology: clinical research, 261(1), pp. 19-27. Wiley 10.1002/path.6146

Willis, Joseph; Anders, Robert A; Torigoe, Toshihiko; Hirohashi, Yoshihiko; Bifulco, Carlo; Zlobec, Inti; Mlecnik, Bernhard; Demaria, Sandra; Choi, Won-Tak; Dundr, Pavel; Tatangelo, Fabiana; Di Mauro, Annabella; Baldin, Pamela; Bindea, Gabriela; Marliot, Florence; Haicheur, Nacilla; Fredriksen, Tessa; Kirilovsky, Amos; Buttard, Bénédicte; Vasaturo, Angela; ... (2023). Multi-Institutional Evaluation of Pathologists' Assessment Compared to Immunoscore. Cancers, 15(16) MDPI AG 10.3390/cancers15164045

Karamitopoulou, Eva; Wenning, Anna Silvia; Acharjee, Animesh; Zlobec, Inti; Aeschbacher, Pauline; Perren, Aurel; Gloor, Beat (2023). Spatially restricted tumour-associated and host-associated immune drivers correlate with the recurrence sites of pancreatic cancer. Gut, 72(8), pp. 1523-1533. BMJ Publishing Group 10.1136/gutjnl-2022-329371

Khan, Amjad; Brouwer, Nelleke; Blank, Annika; Müller, Felix; Soldini, Davide; Noske, Aurelia; Gaus, Elisabeth; Brandt, Simone; Nagtegaal, Iris; Dawson, Heather; Thiran, Jean-Philippe; Perren, Aurel; Lugli, Alessandro; Zlobec, Inti (2023). Computer-Assisted Diagnosis of Lymph Node Metastases in Colorectal Cancers Using Transfer Learning With an Ensemble Model. Modern pathology, 36(5), p. 100118. Springer Nature 10.1016/j.modpat.2023.100118

Frei, Ana Leni; Khan, Amjad; Zens, Philipp; Lugli, Alessandro; Zlobec, Inti; Fischer, Andreas (28 April 2023). GammaFocus: An image augmentation method to focus model attention for classification. In: Medical Imaging with Deep Learning 2023.

Frei, Ana Leni; Khan, Amjad; Studer, Linda; Zens, Philipp; Lugli, Alessandro; Fischer, Andreas; Zlobec, Inti (28 April 2023). Local and global feature aggregation for accurate epithelial cell classification using graph attention mechanisms in histopathology images. In: Medical Imaging with deep Learning 2023.

Bokhorst, John-Melle; Nagtegaal, Iris D; Zlobec, Inti; Dawson, Heather; Sheahan, Kieran; Simmer, Femke; Kirsch, Richard; Vieth, Michael; Lugli, Alessandro; van der Laak, Jeroen; Ciompi, Francesco (2023). Semi-Supervised Learning to Automate Tumor Bud Detection in Cytokeratin-Stained Whole-Slide Images of Colorectal Cancer. Cancers, 15(7) MDPI AG 10.3390/cancers15072079

Skoworonska, Magdalena; Blank, Annika; Centeno, Irene; Hammer, Caroline; Perren, Aurel; Zlobec, Inti; Rau, Tilman T (2023). Real-life data from standardized preanalytical coding (SPREC) in tissue biobanking and its dual use for sample characterization and process optimization. The journal of pathology: clinical research, 9(2), pp. 137-148. Wiley 10.1002/cjp2.305

Ferguson, L Paige; Gatchalian, Jovylyn; McDermott, Matthew L; Nakamura, Mari; Chambers, Kendall; Rajbhandari, Nirakar; Lytle, Nikki K; Rosenthal, Sara Brin; Hamilton, Michael; Albini, Sonia; Wartenberg, Martin; Zlobec, Inti; Galván Hernández, José Alberto; Karamitopoulou, Eva; Vavinskaya, Vera; Wascher, Alexis; Lowy, Andrew M; Schürch, Christian M; Puri, Pier Lorenzo; Bruneau, Benoit G; ... (2023). Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma. Nature Communications, 14(1), p. 292. Springer Nature 10.1038/s41467-023-35796-7

Mlecnik, Bernhard; Lugli, Alessandro; Bindea, Gabriela; Marliot, Florence; Bifulco, Carlo; Lee, Jiun-Kae Jack; Zlobec, Inti; Rau, Tilman T; Berger, Martin D; Nagtegaal, Iris D; Vink-Börger, Elisa; Hartmann, Arndt; Geppert, Carol I; Kolwelter, Julie; Merkel, Susanne; Grützmann, Robert; Van den Eynde, Marc; Jouret-Mourin, Anne; Kartheuser, Alex; Léonard, Daniel; ... (2023). Multicenter International Study of the Consensus Immunoscore for the Prediction of Relapse and Survival in Early-Stage Colon Cancer. Cancers, 15(2) MDPI AG 10.3390/cancers15020418

Jungen, Samuel H; Noti, Luca; Christe, Lucine; Galvan, Jose A; Zlobec, Inti; Müller, Michael D; Imboden, Sara; Siegenthaler, Franziska; Carlson, Joseph W; Pellinen, Teijo; Heredia-Soto, Victoria; Ruz-Caracuel, Ignacio; Hardisson, David; Redondo, Andres; Mendiola, Marta; Rau, Tilman T (2023). Spatial distribution of CD3- and CD8-positive lymphocytes as pretest for POLE wild-type in molecular subgroups of endometrial carcinoma. Frontiers in medicine, 10(1110529), p. 1110529. Frontiers 10.3389/fmed.2023.1110529

2022

Zeng, Qiqun; Saghafinia, Sadegh; Chryplewicz, Agnieszka; Fournier, Nadine; Christe, Lucine; Xie, Yu-Qing; Guillot, Jeremy; Yucel, Simge; Li, Pumin; Galván, José A; Karamitopoulou, Eva; Zlobec, Inti; Ataca, Dalya; Gallean, Fleuriane; Zhang, Peng; Rodríguez-Calero, José Antonio; Rubin, Mark; Tichet, Mélanie; Homicsko, Krisztian and Hanahan, Douglas (2022). Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion. Science, 378(6621), eabl7207. American Association for the Advancement of Science 10.1126/science.abl7207

Janowczyk, Andrew; Baumhoer, Daniel; Dirnhofer, Stefan; Grobholz, Rainer; Kipar, Anja; de Leval, Laurence; Merkler, Doron; Michielin, Olivier; Moch, Holger; Perren, Aurel; Rottenberg, Sven; Rubbia-Brandt, Laura; Rubin, Mark A; Sempoux, Christine; Tolnay, Markus; Zlobec, Inti; Koelzer, Viktor Hendrik (2022). Towards a national strategy for digital pathology in Switzerland. Virchows Archiv, 481(4), pp. 647-652. Springer 10.1007/s00428-022-03345-0

Noti, Luca; Galván, José; Dawson, Heather; Lugli, Alessandro; Kirsch, Richard; Assarzadegan, Naziheh; Messenger, David; Krebs, Philippe; Berger, Martin D; Zlobec, Inti (2022). A combined spatial score of granzyme B and CD68 surpasses CD8 as an independent prognostic factor in TNM stage II colorectal cancer. BMC cancer, 22(1), p. 987. BioMed Central 10.1186/s12885-022-10048-x

Mlecnik, Bernhard; Torigoe, Toshihiko; Bindea, Gabriela; Popivanova, Boryana; Xu, Mingli; Fujita, Tomonobu; Hazama, Shoichi; Suzuki, Nobuaki; Nagano, Hiroaki; Okuno, Kiyotaka; Hirohashi, Yoshihiko; Furuhata, Tomohisa; Takemasa, Ichiro; Patel, Prabhudas; Vora, Hemangini; Shah, Birva; Patel, Jayendrakumar B; Rajvik, Kruti N; Pandya, Shashank J; Shukla, Shilin N; ... (2022). Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study. Cancers, 14(18) MDPI AG 10.3390/cancers14184346

Benhamou, Simone; Fournier, Evelyne; Puppa, Giacomo; McKee, Thomas; Ris, Frédéric; Rubbia-Brandt, Laura; Viassolo, Valeria; Zilli, Thomas; Zlobec, Inti; Chappuis, Pierre Olivier; Rapiti, Elisabetta (2022). Cohort profile: population-based cohorts of patients with colorectal cancer and of their relatives in Geneva, Switzerland. BMJ open, 12(8), e063914. BMJ Publishing Group 10.1136/bmjopen-2022-063914

Abbet, Christian; Studer, Linda; Fischer, Andreas; Dawson, Heather; Zlobec, Inti; Bozorgtabar, Behzad; Thiran, Jean-Philippe (2022). Self-rule to multi-adapt: Generalized multi-source feature learning using unsupervised domain adaptation for colorectal cancer tissue detection. Medical image analysis, 79(102473), p. 102473. Elsevier 10.1016/j.media.2022.102473

Ten Hoorn, Sanne; Waasdorp, Cynthia; van Oijen, Martijn G H; Damhofer, Helene; Trinh, Anne; Zhao, Lan; Smits, Lisanne J H; Bootsma, Sanne; van Pelt, Gabi W; Mesker, Wilma E; Mol, Linda; Goey, Kaitlyn K H; Koopman, Miriam; Medema, Jan Paul; Tuynman, Jurriaan B; Zlobec, Inti; Punt, Cornelis J A; Vermeulen, Louis; Bijlsma, Maarten F (2022). Serum-based measurements of stromal activation through ADAM12 associate with poor prognosis in colorectal cancer. BMC cancer, 22(1), p. 394. BioMed Central 10.1186/s12885-022-09436-0

Rumberger, Josef Lorenz; Baumann, Elias; Hirsch, Peter; Janowczyk, Andrew; Zlobec, Inti; Kainmueller, Dagmar (28 March 2022). Panoptic segmentation with highly imbalanced semantic labels. In: 2022 IEEE International Symposium on Biomedical Imaging Challenges (ISBIC). 10.1109/ISBIC56247.2022.9854551

Nguyen, Huu-Giao; Lundström, Oxana; Blank, Annika; Dawson, Heather; Lugli, Alessandro; Anisimova, Maria; Zlobec, Inti (2022). Image-based assessment of extracellular mucin-to-tumor area predicts consensus molecular subtypes (CMS) in colorectal cancer. Modern pathology, 35(2), pp. 240-248. Springer Nature 10.1038/s41379-021-00894-8

Khan, Amjad; Janowczyk, Andrew; Müller, Felix; Blank, Annika; Nguyen, Huu Giao; Abbet, Christian; Studer, Linda; Lugli, Alessandro; Dawson, Heather; Thiran, Jean-Philippe; Zlobec, Inti (2022). Impact of scanner variability on lymph node segmentation in computational pathology. Journal of pathology informatics, 13(100127), p. 100127. Elsevier 10.1016/j.jpi.2022.100127

2021

Zlobec, Inti; Bächli, Melanie; Galuppini, Francesca; Berger, Martin D.; Dawson, Heather E.; Nagtegaal, Iris D; Lugli, Alessandro (2021). Refining the ITBCC tumor budding scoring system with a "zero-budding" category in colorectal cancer. Virchows Archiv, 479(6), pp. 1085-1090. Springer 10.1007/s00428-021-03090-w

Kandasamy, Palanivel; Zlobec, Inti; Nydegger, Damian T.; Pujol-Gimenez, Jonai; Bhardwaj, Rajesh; Shirasawa, Senji; Tsunoda, Toshiyuki; Hediger, Matthias A. (2021). Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1. Molecular oncology, 15(10), pp. 2782-2800. Wiley 10.1002/1878-0261.12999

Haddad, Tariq Sami; Lugli, Alessandro; Aherne, Susan; Barresi, Valeria; Terris, Benoît; Bokhorst, John-Melle; Brockmoeller, Scarlet Fiona; Cuatrecasas, Miriam; Simmer, Femke; El-Zimaity, Hala; Fléjou, Jean-François; Gibbons, David; Cathomas, Gieri; Kirsch, Richard; Kuhlmann, Tine Plato; Langner, Cord; Loughrey, Maurice B; Riddell, Robert; Ristimäki, Ari; Kakar, Sanjay; ... (2021). Improving tumor budding reporting in colorectal cancer: a Delphi consensus study. Virchows Archiv, 479(3), pp. 459-469. Springer 10.1007/s00428-021-03059-9

Zysset, Daniel; Montani, Matteo; Spalinger, Johannes; Schibli, Susanne; Zlobec, Inti; Mueller, Christoph; Sokollik, Christiane (2021). Molecular and Histological Profiling Reveals an Innate-Shaped Immune Microenvironment in Solitary Juvenile Polyps. Clinical and translational gastroenterology, 12(6), e00361. Wolters Kluwer Health 10.14309/ctg.0000000000000361

Georges, Nadine DF; Oberli, Beatrice; Rau, Tilman; Galván, José; Nagtegaal, Iris D; Dawson, Heather; Blank, Annika; Kohler, Andreas; Lugli, Alessandro; Zlobec, Inti (2021). Tumour budding and CD8+ T-cells: "attackers" and "defenders" in rectal cancer with and without neoadjuvant chemoradiotherapy. Histopathology, 78(7), pp. 1009-1018. Wiley 10.1111/his.14319

Bellanger, Anne-Pauline; Wang, Junhua; Gbaguidi-Haore, Houssein; Barrera, Coralie; Bresson-Hadni, Solange; Zlobec, Inti; Lachenmayer, Anja; Richou, Carine; Turco, Celia; Gottstein, Bruno; Millon, Laurence; Beldi, Guido (2021). Investigating new serological and tissue markers for the follow-up of patients operated for alveolar echinococcosis. Parasite immunology, 43(6), e12827. Wiley 10.1111/pim.12827

Koelzer, V H; Herzig, P; Zlobec, Inti; Heinzelmann, V; Lardinois, D; Walseng, E; Rader, C; Mertz, K D; Zippelius, A; Thommen, D S (2021). Integrated functional and spatial profiling of tumour immune responses induced by immunotherapy: the iPROFILER platform. Immuno-oncology technology, 10(C) Elsevier 10.1016/j.iotech.2021.100034

Karamitopoulou, Evanthia; Esposito, Irene; Zlobec, Inti; Insilla, Andrea Cacciato; Wartenberg, Martin; Schaeffer, David F; Kalloger, Steve; La Rosa, Stefano; Sempoux, Christine; Ramos Centeno, Irene; Lohneis, Philipp (2021). Reproducibility of tumor budding assessment in pancreatic cancer based on a multicenter interobserver study. Virchows Archiv, 478(4), pp. 719-726. Springer 10.1007/s00428-020-02987-2

Studer, Linda; Blank, Annika; Bokhorst, John-Melle; Nagtegaal, Iris D; Zlobec, Inti; Lugli, Alessandro; Fischer, Andreas; Dawson, Heather (2021). Taking Tumour Budding to the Next Frontier - a Post-ITBCC 2016 Review. Histopathology, 78(4), pp. 476-484. Wiley 10.1111/his.14267

Guo, Yuchen; Gabola, Monica; Lattanzio, Rossano; Paul, Conception; Pinet, Valérie; Tang, Ruizhi; Turali, Hulya; Bremond, Julie; Longobardi, Ciro; Maurizy, Chloé; Da Costa, Quentin; Finetti, Pascal; Boissière-Michot, Florence; Rivière, Benjamin; Lemmers, Céline; Garnier, Séverine; Bertucci, François; Zlobec, Inti; Chebli, Karim; Tazi, Jamal; ... (2021). Cyclin A2 maintains colon homeostasis and is a prognostic factor in CRC. The journal of clinical investigation, 131(4) American Society for Clinical Investigation 10.1172/JCI131517

Lugli, Alessandro; Zlobec, Inti; Berger, Martin D.; Kirsch, Richard; Nagtegaal, Iris D (2021). Tumour budding in solid cancers. Nature reviews. Clinical oncology, 18(2), pp. 101-115. Springer Nature 10.1038/s41571-020-0422-y

Nguyen, Huu-Giao; Blank, Annika; Dawson, Heather E.; Lugli, Alessandro; Zlobec, Inti (2021). Classification of colorectal tissue images from high throughput tissue microarrays by ensemble deep learning methods. Scientific reports, 11(1), p. 2371. Springer Nature 10.1038/s41598-021-81352-y

Rau, Tilman T.; Bettschen, Eva; Büchi, Carol; Christe, Lucine; Rohner, Amanda; Müller, Michael D.; Carlson, Joseph W; Imboden, Sara; Zlobec, Inti (2021). Prognostic impact of tumor budding in endometrial carcinoma within distinct molecular subgroups. Modern pathology, 34(1), pp. 222-232. Springer Nature 10.1038/s41379-020-0626-9

Elvebakken, Hege; Perren, A.; Scoazec, Jean-Yves; Tang, Laura H; Federspiel, Birgitte; Klimstra, David S; Vestermark, Lene W; Ali, Abir S; Zlobec, I.; Myklebust, Tor Å; Hjortland, Geir O; Langer, Seppo W; Gronbæk, Henning; Knigge, Ulrich; Tiensuu Janson, Eva; Sorbye, Halfdan (2021). A consensus developed morphological re-evaluation of 196 high-grade gastroenteropancreatic neuroendocrine neoplasms and its clinical correlations. Neuroendocrinology, 111(9), pp. 883-894. Karger 10.1159/000511905

Burren, Sandra; Reche, Katharina; Blank, Annika; Galván, José A.; Dawson, Heather; Berger, Martin D.; Zlobec, Inti; Lugli, Alessandro (2021). RHAMM in liver metastases of stage IV colorectal cancer with mismatch-repair proficient status correlates with tumor budding, cytotoxic T-cells and PD-1/PD-L1. Pathology, research and practice, 223, p. 153486. Elsevier 10.1016/j.prp.2021.153486

Rhyner Agocs, Gaëlle; Assarzadegan, Naziheh; Kirsch, Richard; Dawson, Heather; Galván, José A.; Lugli, Alessandro; Zlobec, Inti; Berger, Martin D. (2021). LAG-3 Expression Predicts Outcome in Stage II Colon Cancer. Journal of personalized medicine, 11(8) MDPI 10.3390/jpm11080749

Jiang, Sizun; Mukherjee, Nilanjan; Bennett, Richard S; Chen, Han; Logue, James; Dighero-Kemp, Bonnie; Kurtz, Jonathan R; Adams, Ricky; Phillips, Darci; Schürch, Christian M; Goltsev, Yury; Hickey, John W; McCaffrey, Erin F; Delmastro, Alea; Chu, Pauline; Reader, J Rachel; Keesler, Rebekah I; Galván, José A.; Zlobec, Inti; Van Rompay, Koen K A; ... (2021). Rhesus Macaque CODEX Multiplexed Immunohistochemistry Panel for Studying Immune Responses During Ebola Infection. Frontiers in immunology, 12, p. 729845. Frontiers Research Foundation 10.3389/fimmu.2021.729845

2020

Mlecnik, Bernhard; Bifulco, Carlo; Bindea, Gabriela; Marliot, Florence; Lugli, Alessandro; Lee, J Jack; Zlobec, Inti; Rau, Tilman T.; Berger, Martin D.; Nagtegaal, Iris D; Vink-Börger, Elisa; Hartmann, Arndt; Geppert, Carol; Kolwelter, Julie; Merkel, Susanne; Grützmann, Robert; Van den Eynde, Marc; Jouret-Mourin, Anne; Kartheuser, Alex; Léonard, Daniel; ... (2020). Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer. Journal of clinical oncology, 38(31), pp. 3638-3651. American Society of Clinical Oncology 10.1200/JCO.19.03205

Schürch, Christian M; Bhate, Salil S; Barlow, Graham L; Phillips, Darci J; Noti, Luca; Zlobec, Inti; Chu, Pauline; Black, Sarah; Demeter, Janos; McIlwain, David R; Kinoshita, Shigemi; Samusik, Nikolay; Goltsev, Yury; Nolan, Garry P (2020). Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front. Cell, 183(3), p. 838. Cell Press 10.1016/j.cell.2020.10.021

Schürch, Christian M; Bhate, Salil S; Barlow, Graham L; Phillips, Darci J; Noti, Luca; Zlobec, Inti; Chu, Pauline; Black, Sarah; Demeter, Janos; McIlwain, David R; Kinoshita, Shigemi; Samusik, Nikolay; Goltsev, Yury; Nolan, Garry P (2020). Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front. Cell, 182(5), 1341-1359.e19. Cell Press 10.1016/j.cell.2020.07.005

Zlobec, Inti; Berger, Martin D.; Lugli, Alessandro (2020). Tumour budding and its clinical implications in gastrointestinal cancers. British journal of cancer, 123(5), pp. 700-708. Nature Publishing Group 10.1038/s41416-020-0954-z

Contat, Caroline; Ancey, Pierre-Benoit; Zangger, Nadine; Sabatino, Silvia; Pascual, Justine; Escrig, Stéphane; Jensen, Louise; Goepfert, Christine; Lanz, Bernard; Lepore, Mario; Gruetter, Rolf; Rossier, Anouk; Berezowska, Sabina; Neppl, Christina; Zlobec, Inti; Clerc-Rosset, Stéphanie; Knott, Graham William; Rathmell, Jeffrey C; Abel, E Dale; Meibom, Anders; ... (2020). Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth. eLife, 9 eLife Sciences Publications 10.7554/eLife.53618

Liu, He; He, Zhaoyue; Germič, Nina; Ademi, Hyrijie; Frangež, Živa; Felser, Andrea; Peng, Shuang; Riether, Carsten; Djonov, Valentin; Nuoffer, Jean-Marc; Bovet, Cédric; Mlinarič-Raščan, Irena; Zlobec, Inti; Fiedler, Georg; Perren, Aurel; Simon, Hans-Uwe (2020). ATG12 deficiency leads to tumor cell oncosis owing to diminished mitochondrial biogenesis and reduced cellular bioenergetics. Cell death and differentiation, 27(6), pp. 1965-1980. Springer Nature 10.1038/s41418-019-0476-5

Unternaehrer, Julia; Grobholz, Rainer; Janowczyk, Andrew; Zlobec, Inti (2020). Current opinion, status and future development of digital pathology in Switzerland. Journal of clinical pathology, 73(6), pp. 341-346. BMJ Publishing Group 10.1136/jclinpath-2019-206155

Neppl, Christina; Zlobec, Inti; Schmid, Ralph A.; Berezowska, Sabina Anna (2020). Validation of the International Tumor Budding Consensus Conference (ITBCC) 2016 recommendation in squamous cell carcinoma of the lung-a single-center analysis of 354 cases. Modern pathology, 33(5), pp. 802-811. Springer Nature 10.1038/s41379-019-0413-7

Bokhorst, J. M.; Blank, A.; Lugli, A.; Zlobec, I.; Dawson, H.; Vieth, M.; Rijstenberg, L. L.; Brockmoeller, S.; Urbanowicz, M.; Flejou, J. F.; Kirsch, R.; Ciompi, F.; van der Laak, J. A. W. M.; Nagtegaal, I. D. (2020). Assessment of individual tumor buds using keratin immunohistochemistry: moderate interobserver agreement suggests a role for machine learning. Modern pathology, 33(5), pp. 825-833. Springer Nature 10.1038/s41379-019-0434-2

Zlobec, Inti; Dawson, Heather E.; Blank, Annika; Bokhorst, John-Melle; Berger, Martin D.; Nagtegaal, Iris D; Lugli, Alessandro (2020). Are tumour grade and tumour budding equivalent in colorectal cancer? A retrospective analysis of 771 patients. European journal of cancer, 130, pp. 139-145. Elsevier 10.1016/j.ejca.2020.02.007

Dawson, Heather; Christe, Lucine; Eichmann, Micha; Reinhard, Stefan; Zlobec, Inti; Blank, Annika; Lugli, Alessandro (2020). Tumour Budding/T-cell infiltrates in Colorectal Cancer: Proposal of a Novel Combined Score. Histopathology, 76(4), pp. 572-580. Wiley 10.1111/his.14006

Bozorgtabar, Behzad; Mahapatra, Dwarikanath; Zlobec, Inti; Rau, Tilman T.; Thiran, Jean-Philippe (2020). Editorial: Computational Pathology. Frontiers in medicine, 7(245), p. 245. Frontiers 10.3389/fmed.2020.00245

Lugli, Alessandro; Zlobec, Inti (2020). The battle for prognosis at the invasive front of colorectal cancer. EBioMedicine, 58, p. 102918. Elsevier 10.1016/j.ebiom.2020.102918

Abbet, Christian; Zlobec, Inti; Bozorgtabar, Behzad; Thiran, Jean-Philippe (2020). Divide-and-Rule: Self-Supervised Learning for Survival Analysis in Colorectal Cancer. In: Martel, Anne L.; Abolmaesumi, Purang; Stoyanov, Danail; Mateus, Diana; Zuluaga, Maria A.; Zhou, S. Kevin; Racoceanu, Daniel; Joskowicz, Leo (eds.) Medical Image Computing and Computer Assisted Intervention – MICCAI 2020. Lecture Notes in Computer Science: Vol. 12265 (pp. 480-489). Cham: Springer International Publishing 10.1007/978-3-030-59722-1_46

2019

Lavanchy, Joël L.; Vaisnora, Lukas; Haltmeier, Tobias; Zlobec, Inti; Brügger, Lukas E.; Candinas, Daniel; Schnüriger, Beat (2019). Oncologic long-term outcomes of emergency versus elective resection for colorectal cancer. International journal of colorectal disease, 34(12), pp. 2091-2099. Springer 10.1007/s00384-019-03426-8

Kappel, Sven; Stoklosa, Paulina; Hauert, Barbara; Ross-Kaschitza, Daniela; Borgström, Anna; Baur, Roland; Galván, José A.; Zlobec, Inti; Peinelt, Christine (2019). TRPM4 is highly expressed in human colorectal tumor buds and contributes to proliferation, cell cycle, and invasion of colorectal cancer cells. Molecular oncology, 13(11), pp. 2393-2405. FEBS Press 10.1002/1878-0261.12566

Anso, Juan; Dür, Cilgia; Apelt, Mareike; Venail, Frederic; Scheidegger, Oliver; Seidel, Kathleen; Rohrbach, Helene; Forterre, Franck; Dettmer, Matthias S.; Zlobec, Inti; Weber, Klaus; Matulic, Marco; Zoka-Assadi, Masoud; Huth, Markus; Caversaccio, Marco; Weber, Stefan (2019). Prospective Validation of Facial Nerve Monitoring to Prevent Nerve Damage During Robotic Drilling. Frontiers in Surgery, 6(58), p. 58. Frontiers 10.3389/fsurg.2019.00058

Pastille, Eva; Wasmer, Marie-Hélène Christin; Adamczyk, Alexandra; Vu, Vivian Pham; Mager, Lukas F; Phuong, Nhi Ngo Thi; Palmieri, Vittoria; Simillion, Cedric André Marie; Hansen, Wiebke; Kasper, Stefan; Schuler, Martin; Muggli, Beat; McCoy, Kathy D; Buer, Jan; Zlobec, Inti; Westendorf, Astrid M; Krebs, Philippe (2019). The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer. Mucosal immunology, 12(4), pp. 990-1003. Nature Publishing Group 10.1038/s41385-019-0176-y

Dawson, Heather; Galuppini, Francesca; Träger, Peter; Berger, Martin D.; Studer, Peter; Brügger, Lukas; Zlobec, Inti; Inderbitzin, Daniel; Lugli, Alessandro (2019). Validation of the international tumor budding consensus conference (ITBCC 2016) recommendations on tumor budding in stage I-IV colorectal cancer. Human pathology, 85, pp. 145-151. Elsevier 10.1016/j.humpath.2018.10.023

Wyss, Jacqueline; Dislich, Bastian; Kölzer, Viktor; Galván, José A.; Dawson, Heather; Hädrich, Marion; Inderbitzin, Daniel; Lugli, Alessandro; Zlobec, Inti; Berger, Martin D. (2019). Stromal PD-1/PD-L1 Expression Predicts Outcome in Colon Cancer Patients. Clinical colorectal cancer, 18(1), e20-e38. Elsevier 10.1016/j.clcc.2018.09.007

Zeng, Qiqun; Michael, Iacovos P.; Zhang, Peng; Saghafinia, Sadegh; Knott, Graham; Jiao, Wei; McCabe, Brian D.; Galván, José A.; Robinson, Hugh P. C.; Zlobec, Inti; Ciriello, Giovanni; Hanahan, Douglas (2019). Synaptic proximity enables NMDAR signalling to promote brain metastasis. Nature, 573(7775), pp. 526-531. Springer Nature 10.1038/s41586-019-1576-6

Georges, Laurent M. C.; De Wever, Olivier; Galván, José A.; Dawson, Heather; Lugli, Alessandro; Demetter, Pieter; Zlobec, Inti (2019). Cell Line Derived Xenograft Mouse Models Are a Suitable in vivo Model for Studying Tumor Budding in Colorectal Cancer. Frontiers in medicine, 6(139), p. 139. Frontiers 10.3389/fmed.2019.00139

Lytle, Nikki K.; Ferguson, L. Paige; Rajbhandari, Nirakar; Gilroy, Kathryn; Fox, Raymond G.; Deshpande, Anagha; Schürch, Christian M.; Hamilton, Michael; Robertson, Neil; Lin, Wei; Noel, Pawan; Wartenberg, Martin; Zlobec, Inti; Eichmann, Micha David; Galván, José A.; Karamitopoulou, Evanthia; Gilderman, Tami; Esparza, Lourdes Adriana; Shima, Yutaka; Spahn, Philipp; ... (2019). A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma. Cell, 177(3), 572-586.e22. Cell Press 10.1016/j.cell.2019.03.010

Meyer, Sara N.; Galván, José A.; Zahnd, Stefan; Sokol, Lena; Dawson, Heather; Lugli, Alessandro; Zlobec, Inti (2019). Co-expression of cytokeratin and vimentin in colorectal cancer highlights a subset of tumor buds and an atypical cancer-associated stroma. Human pathology, 87, pp. 18-27. Elsevier 10.1016/j.humpath.2019.02.002

Neppl, Christina; Keller, Manuel D; Scherz, Amina; Dorn, Patrick; Schmid, Ralph A.; Zlobec, Inti; Berezowska, Sabina (2019). Comparison of the 7th and 8th Edition of the UICC/AJCC TNM Staging System in Primary Resected Squamous Cell Carcinomas of the Lung-A Single Center Analysis of 354 Cases. Frontiers in medicine, 6(196), p. 196. Frontiers 10.3389/fmed.2019.00196

Blank, Annika; Schenker, Carla; Dawson, Heather; Beldi, Guido; Zlobec, Inti; Lugli, Alessandro (2019). Evaluation of Tumor Budding in Primary Colorectal Cancer and Corresponding Liver Metastases Based on H&E and Pancytokeratin Staining. Frontiers in medicine, 6, p. 247. Frontiers 10.3389/fmed.2019.00247

2018

Trinh, Anne; Lädrach, Claudia; Dawson, Heather E.; Ten Hoorn, Sanne; Kuppen, Peter J K; Reimers, Marlies S; Koopman, Miriam; Punt, Cornelis J A; Lugli, Alessandro; Vermeulen, Louis; Zlobec, Inti (2018). Tumour budding is associated with the mesenchymal colon cancer subtype and RAS/RAF mutations: a study of 1320 colorectal cancers with Consensus Molecular Subgroup (CMS) data. British journal of cancer, 119(10), pp. 1244-1251. Nature Publishing Group 10.1038/s41416-018-0230-7

Graule, Janina; Uth-Gottardi, Kristin; Fischer, Elia Luca; Centeno Ramos, Irene; Galván Hernández, José Alberto; Eichmann, Micha David; Rau, Tilman; Langer, Rupert; Dawson, Heather; Nitsche, Ulrich; Traeger, Peter; Berger, Martin Dave; Schnüriger, Beat; Hädrich, Marion; Studer, Peter; Inderbitzin, Daniel; Lugli, Alessandro; Tschan, Mario; Zlobec, Inti (2018). CDX2 in colorectal cancer is an independent prognostic factor and regulated by promoter methylation and histone deacetylation in tumors of the serrated pathway. Clinical epigenetics, 10(1), p. 120. Springer 10.1186/s13148-018-0548-2

Wartenberg, Martin; Cibin, Silvia; Zlobec, Inti; Vassella, Erik; Eppenberger-Castori, Serenella; Terracciano, Luigi; Eichmann, Micha David; Worni, Mathias; Gloor, Beat; Perren, Aurel; Karamitopoulou, Evanthia (2018). Integrated Genomic and Immunophenotypic Classification of Pancreatic Cancer Reveals Three Distinct Subtypes with Prognostic/Predictive Significance. Clinical cancer research, 24(18), pp. 4444-4454. American Association for Cancer Research 10.1158/1078-0432.CCR-17-3401

Karamitopoulou, Evanthia; Wartenberg, Martin; Zlobec, Inti; Cibin, Silvia; Worni, Mathias; Gloor, Beat; Lugli, Alessandro (2018). Tumour budding in pancreatic cancer revisited: validation of the ITBCC scoring system. Histopathology, 73(1), pp. 137-146. Wiley 10.1111/his.13508

Pagès, Franck; Mlecnik, Bernhard; Marliot, Florence; Bindea, Gabriela; Ou, Fang-Shu; Bifulco, Carlo; Lugli, Alessandro; Zlobec, Inti; Rau, Tilman T.; Berger, Martin D.; Nagtegaal, Iris D; Vink-Börger, Elisa; Hartmann, Arndt; Geppert, Carol; Kolwelter, Julie; Merkel, Susanne; Grützmann, Robert; Van den Eynde, Marc; Jouret-Mourin, Anne; Kartheuser, Alex; ... (2018). International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study. Lancet, 391(10135), pp. 2128-2139. Elsevier 10.1016/S0140-6736(18)30789-X

Zlobec, Inti; Lugli, Alessandro (2018). Tumour budding in colorectal cancer: molecular rationale for clinical translation. Nature reviews - cancer, 18(4), pp. 203-204. Nature Publishing Group 10.1038/nrc.2018.1

Vavricka, Stephan R; Galván Hernández, José Alberto; Dawson, Heather; Soltermann, Alex; Biedermann, Luc; Scharl, Michael; Schoepfer, Alain M; Rogler, Gerhard; Prinz Vavricka, Mareike B; Terracciano, Luigi; Navarini, Alexander; Zlobec, Inti; Lugli, Alessandro; Greuter, Thomas (2018). Expression Patterns of TNFα, MAdCAM1 and STAT3 in Intestinal and Skin Manifestations of Inflammatory Bowel Disease. Journal of Crohn's & colitis, 12(3), pp. 347-354. Oxford University Press 10.1093/ecco-jcc/jjx158

Kröll, Dino; Noser, Laura; Erdem, Suna; Zlobec, Inti; Storni, Federico Lorenzo; Arnold, Dominik; Dislich, Bastian; Seiler, Christian A.; Candinas, Daniel; Langer, Rupert (2018). Application of the 8th edition of the AJCC yTNM staging system shows improved prognostication in a single center cohort of esophageal carcinomas. Surgical oncology, 27(1), pp. 100-105. Elsevier 10.1016/j.suronc.2017.12.005

Laedrach, C; Salhia, B; Cihoric, Nikola; Zlobec, Inti; Tapia, C (2018). Immunophenotypic profile of tumor buds in breast cancer. Pathology, research and practice, 214(1), pp. 25-29. Elsevier 10.1016/j.prp.2017.11.023

Li, Leanne; Zeng, Qiqun; Bhutkar, Arjun; Galván Hernández, José Alberto; Karamitopoulou, Evanthia; Noordermeer, Daan; Peng, Mei-Wen; Piersigilli, Alessandra; Perren, Aurel; Zlobec, Inti; Robinson, Hugh; Iruela-Arispe, M. Luisa; Hanahan, Douglas (2018). GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth. Cancer cell, 33(4), 736-751.e5. Cell Press 10.1016/j.ccell.2018.02.011

Blank, Annika; Roberts, Daniel Edward; Dawson, Heather; Zlobec, Inti; Lugli, Alessandro (2018). Tumor Heterogeneity in Primary Colorectal Cancer and Corresponding Metastases. Does the Apple Fall Far From the Tree? Frontiers in medicine, 5, p. 234. Frontiers 10.3389/fmed.2018.00234

2017

Faget, Julien; Groeneveld, Svenja; Boivin, Gael; Sankar, Martial; Zangger, Nadine; Garcia, Miguel; Guex, Nicolas; Zlobec, Inti; Steiner, Loïc; Piersigilli, Alessandra; Xenarios, Ioannis; Meylan, Etienne (2017). Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer. Cell reports, 21(11), pp. 3190-3204. Cell Press 10.1016/j.celrep.2017.11.052

Saurer, Leslie; Zysset, Daniel; Rihs, Silvia; Mager, Lukas; Gusberti, Matteo; Simillion, Cedric; Lugli, Alessandro; Zlobec, Inti; Krebs, Philippe; Müller, Christoph (2017). TREM-1 promotes intestinal tumorigenesis. Scientific Reports, 7(1), p. 14870. Nature Publishing Group 10.1038/s41598-017-14516-4

Mager, Lukas Franz; Kölzer, Viktor Hendrik; Stuber Roos, Regula; Thoo Sin Lang, Lester; Keller, Irene; Köck, Ivonne; Langenegger, Maya; Simillion, Cedric; Pfister, Simona P; Faderl, Martin Richard; Genitsch Gratwohl, Vera; Tcymbarevich, Irina; Juillerat, Pascal; Li, Xiaohong; Xia, Yu; Karamitopoulou, Evanthia; Lyck, Ruth; Zlobec, Inti; Hapfelmeier, Siegfried Hektor; Bruggmann, Rémy; ... (2017). The ESRP1-GPR137 axis contributes to intestinal pathogenesis. eLife, 6 eLife Sciences Publications 10.7554/eLife.28366

Sartori, Elsa; Langer, Rupert; Vassella, Erik; Hewer, Ekkehard; Schucht, Philippe; Zlobec, Inti; Berezowska, Sabina Anna (2017). Low co-expression of epidermal growth factor receptor and its chaperone heat shock protein 90 is associated with worse prognosis in primary glioblastoma, IDH-wild-type. Oncology reports, 38(4), pp. 2394-2400. Spandidos Publications 10.3892/or.2017.5863

Mele, Valentina; Sokol, Lena; Kölzer, Viktor; Pfaff, Dennis; Muraro, Manuele Giuseppe; Keller, Irene; Zahnd, Stefan Patrick; Centeno Ramos, Irene; Terracciano, Luigi Maria; Dawson, Heather; Zlobec, Inti; Iezzi, Giandomenica; Lugli, Alessandro (2017). The hyaluronan-mediated motility receptor RHAMM promotes growth, invasiveness and dissemination of colorectal cancer. OncoTarget, 8(41), pp. 70617-70629. Impact Journals LLC 10.18632/oncotarget.19904

Lugli, Alessandro; Kirsch, Richard; Ajioka, Yoichi; Bosman, Fred; Cathomas, Gieri; Dawson, Heather; El Zimaity, Hala; Fléjou, Jean-François; Hansen, Tine Plato; Hartmann, Arndt; Kakar, Sanjay; Langner, Cord; Nagtegaal, Iris; Puppa, Giacomo; Riddell, Robert; Ristimäki, Ari; Sheahan, Kieran; Smyrk, Thomas; Sugihara, Kenichi; Terris, Benoît; ... (2017). Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016. Modern pathology, 30(9), pp. 1299-1311. Nature Publishing Group 10.1038/modpathol.2017.46

Niklaus, Monique; Adams, Olivia Joan; Berezowska, Sabina Anna; Zlobec, Inti; Graber, Franziska; Slotta-Huspenina, Julia; Nitsche, Ulrich; Rosenberg, Robert; Tschan, Mario; Langer, Rupert (2017). Expression analysis of LC3B and p62 indicates intact activated autophagy is associated with an unfavorable prognosis in colon cancer. OncoTarget, 8(33), pp. 54604-54615. Impact Journals LLC 10.18632/oncotarget.17554

Genitsch Gratwohl, Vera; Zlobec, Inti; Seiler, Roland; Thalmann, George; Fleischmann, Achim (2017). Neuroendocrine Differentiation in Metastatic Conventional Prostate Cancer Is Significantly Increased in Lymph Node Metastases Compared to the Primary Tumors. International journal of molecular sciences, 18(8) MDPI 10.3390/ijms18081640

Koelzer, Viktor H; Assarzadegan, Naziheh; Dawson, Heather; Mitrovic, Bojana; Grin, Andrea; Messenger, David E; Kirsch, Richard; Riddell, Robert H; Lugli, Alessandro; Zlobec, Inti (2017). Cytokeratin-based assessment of tumour budding in colorectal cancer: analysis in stage II patients and prospective diagnostic experience. The journal of pathology: clinical research, 3(3), pp. 171-178. Wiley 10.1002/cjp2.73

Rieger, Gregor; Kölzer, Viktor; Dawson, Heather; Berger, Martin Dave; Hädrich, Marion; Inderbitzin, Daniel; Lugli, Alessandro; Zlobec, Inti (2017). Comprehensive assessment of tumour budding on cytokeratin stains in colorectal cancer. Histopathology, 70(7), pp. 1044-1051. Blackwell Scientific Publications 10.1111/his.13164

Ivanovska, Jelena; Zlobec, Inti; Forster, Stefan; Karamitopoulou, Evanthia; Dawson, Heather; Koelzer, Viktor Hendrik; Agaimy, Abbas; Garreis, Fabian; Söder, Stephan; Laqua, William; Lugli, Alessandro; Hartmann, Arndt; Rau, Tilman; Schneider-Stock, Regine (2017). Correction: DAPK loss in colon cancer tumor buds: implications for migration capacity of disseminating tumor cells. OncoTarget, 8(11), pp. 18615-18616. Impact Journals LLC 10.18632/oncotarget.16154

Dislich, Bastian; Stein, Alexandra Vanessa; Seiler, Christian A.; Kröll, Dino; Berezowska, Sabina Anna; Zlobec, Inti; Galván Hernández, José Alberto; Slotta-Huspenina, Julia; Walch, Axel; Langer, Rupert (2017). Expression patterns of programmed death-ligand 1 in esophageal adenocarcinomas: comparison between primary tumors and metastases. Cancer immunology, immunotherapy, 66(6), pp. 777-786. Springer 10.1007/s00262-017-1982-2

Nolte, Sarah; Zlobec, Inti; Lugli, Alessandro; Hohenberger, Werner; Croner, Roland; Merkel, Susanne; Hartmann, Arndt; Geppert, Carol I; Rau, Tilman (2017). Construction and analysis of tissue microarrays in the era of digital pathology: a pilot study targeting CDX1 and CDX2 in a colon cancer cohort of 612 patients. The journal of pathology: clinical research, 3(1), pp. 58-70. Wiley 10.1002/cjp2.62

Riether, Carsten; Schürch, Christian M.; Bührer, Elias D.; Hinterbrandner, Magdalena; Huguenin, Anne-Laure; Höpner, Sabine; Zlobec, Inti; Pabst, Thomas; Radpour, Ramin; Ochsenbein, Adrian F. (2017). CD70/CD27 signaling promotes blast stemness and is a viable therapeutic target in acute myeloid leukemia. The Journal of experimental medicine, 214(2), pp. 359-380. Rockefeller Univ. Press 10.1084/jem.20152008

Centeno, Irene; Paasinen Sohns, Aino; Flury, Miriam; Galván, José A.; Zahnd, Stefan; Kölzer, Viktor H.; Sokol, Lena; Dawson, Heather E.; Lugli, Alessandro; Cathomas, Gieri; Zlobec, Inti (2017). DNA profiling of tumor buds in colorectal cancer indicates that they have the same mutation profile as the tumor from which they derive. Virchows Archiv, 470(3), pp. 341-346. Springer 10.1007/s00428-017-2071-9

Noser, Laura; Kröll, Dino; Erdem, Suna; Storni, Federico Lorenzo; Arnold, Dominik; Dislich, Bastian; Zlobec, Inti; Seiler, Christian A.; Langer, Rupert (2017). The 8th edition of the AJCC TNM staging system shows slightly improved, but still not perfect prognostication for esophageal carcinomas treated by neoadjuvant therapy followed by surgery (Unpublished). In: Schweizerische Gesellschaft für Chirurgie Kongress 2017. Bern. 31.5.-2.6.2017.

Kölzer, Viktor; Sokol, Lena; Zahnd, Stefan Patrick; Christe, Lucine; Dawson, Heather; Berger, Martin Dave; Inderbitzin, Daniel; Zlobec, Inti; Lugli, Alessandro (2017). Digital analysis and epigenetic regulation of the signature of rejection in colorectal cancer. Oncoimmunology, 6(4), e1288330. Landes Bioscience 10.1080/2162402X.2017.1288330

2016

Dawson, Heather; Novotny, Alexander; Becker, Karen; Reim, Daniel; Langer, Rupert; Gullo, Irene; Svrcek, Magali; Niess, Jan Hendrik; Tutuian, Radu; Truninger, Kaspar; Diamantis, Ioannis; Blank, Annika; Zlobec, Inti; Riddell, Robert H; Carneiro, Fatima; Fléjou, Jean-François; Genta, Robert M; Lugli, Alessandro (2016). Macroscopy predicts tumor progression in gastric cancer: A retrospective patho-historical analysis based on Napoleon Bonaparte's autopsy report. Digestive and liver disease, 48(11), pp. 1378-1385. Elsevier 10.1016/j.dld.2016.07.013

Genitsch Gratwohl, Vera; Zlobec, Inti; Fleischmann, Achim; Thalmann, George (2016). MUC1 in lymph node metastases independently predicts survival in advanced prostate cancer patients. Prostate Cancer Prostatic Diseases, 19(3), pp. 242-247. Springer 10.1038/pcan.2016.11

Wartenberg, Martin; Centeno, Irene; Haemmig, Stefan; Vassella, Erik; Zlobec, Inti; Galván, José A.; Neuenschwander, Maja; Schlup, Cornelia; Gloor, Beat; Lugli, Alessandro; Perren, Aurel; Karamitopoulou, Evanthia (2016). PTEN alterations of the stromal cells characterise an aggressive subpopulation of pancreatic cancer with enhanced metastatic potential. European journal of cancer, 65, pp. 80-90. Elsevier 10.1016/j.ejca.2016.06.013

Thies, Svenja; Guldener, Lars; Slotta-Huspenina, Julia; Zlobec, Inti; Kölzer, Viktor; Lugli, Alessandro; Kröll, Dino; Seiler, Christian A.; Feith, Marcus; Langer, Rupert (2016). Impact of peritumoral and intratumoral budding in esophageal adenocarcinomas. Human pathology, 52, pp. 1-8. Elsevier 10.1016/j.humpath.2016.01.016

Rau, Tilman; Atreya, Raja; Aust, Daniela; Baretton, Gustavo; Eck, Matthias; Erlenbach-Wünsch, Katharina; Hartmann, Arndt; Lugli, Alessandro; Stöhr, Robert; Vieth, Michael; Wirsing, Anna M; Zlobec, Inti; Katzenberger, Tiemo (2016). Inflammatory response in serrated precursor lesions of the colon classified according to WHO entities, clinical parameters and phenotype-genotype correlation. The journal of pathology: clinical research, 2(2), pp. 113-124. Wiley 10.1002/cjp2.41

Mertz, Kirsten D; Mager, Lukas F.; Wasmer, Marie-Hélène; Thiesler, Thore; Kölzer, Viktor H.; Ruzzante, Giulia; Joller, Stefanie; Murdoch, Jenna R; Brümmendorf, Thomas; Genitsch Gratwohl, Vera; Lugli, Alessandro; Cathomas, Gieri; Moch, Holger; Weber, Achim; Zlobec, Inti; Junt, Tobias; Krebs, Philippe (2016). The IL-33/ST2 pathway contributes to intestinal tumorigenesis in humans and mice. Oncoimmunology, 5(1), e1062966. Landes Bioscience 10.1080/2162402X.2015.1062966

Kölzer, Viktor; Zlobec, Inti; Lugli, Alessandro (2016). Tumor budding in colorectal cancer—ready for diagnostic practice? Human pathology, 47(1), pp. 4-19. Elsevier 10.1016/j.humpath.2015.08.007

2015

Amicarella, F; Muraro, M G; Hirt, C; Cremonesi, E; Padovan, Elisabetta; Mele, V; Governa, V; Han, J; Huber, X; Droeser, R A; Zuber, M; Adamina, M; Bolli, M; Rosso, R; Lugli, Alessandro; Zlobec, Inti; Terracciano, Luigi; Tornillo, L; Zajac, P; Eppenberger-Castori, S; ... (2015). Dual role of tumour-infiltrating T helper 17 cells in human colorectal cancer. Gut, 66(4), pp. 692-704. BMJ Publishing Group 10.1136/gutjnl-2015-310016

Schafroth, Christian; Galván Hernández, José Alberto; Centeno Ramos, Irene; Kölzer, Viktor; Dawson, Heather; Sokol, Lena; Rieger, Gregor; Berger, Martin D; Hädrich, Marion; Rosenberg, Robert; Nitsche, Ulrich; Schnüriger, Beat; Langer, Rupert; Inderbitzin, Daniel; Inderbitzin, Daniel; Lugli, Alessandro; Zlobec, Inti (2015). VE1 immunohistochemistry predicts BRAF V600E mutation status and clinical outcome in colorectal cancer. OncoTarget, 6(39), pp. 41453-41463. Impact Journals LLC 10.18632/oncotarget.6162

Ivanovska, Jelena; Zlobec, Inti; Forster, Stefan; Karamitopoulou, Evanthia; Dawson, Heather; Kölzer, Viktor; Agaimy, Abbas; Garreis, Fabian; Söder, Stephan; Laqua, William; Lugli, Alessandro; Hartmann, Arndt; Rau, Tilman; Schneider-Stock, Regine (2015). DAPK loss in colon cancer tumor buds: implications for migration capacity of disseminating tumor cells. OncoTarget, 6(34), pp. 36774-36788. Impact Journals LLC 10.18632/oncotarget.4908

Kölzer, Viktor; Huber, Bettina; Mele, Valentina; Iezzi, Giandomenica; Trippel, Mafalda; Karamitopoulou, Evanthia; Zlobec, Inti; Lugli, Alessandro (2015). Expression of the hyaluronan-mediated motility receptor RHAMM in tumor budding cells identifies aggressive colorectal cancers. Human pathology, 46(11), pp. 1573-1581. Elsevier 10.1016/j.humpath.2015.07.010

Galli, Serena; Zlobec, Inti; Schürch, Christian; Perren, Aurel; Ochsenbein, Adrian; Banz Wälti, Yara (2015). CD47 protein expression in acute myeloid leukemia: A tissue microarray-based analysis. Leukemia research, 39(7), pp. 749-756. Elsevier 10.1016/j.leukres.2015.04.007

Galván Hernández, José Alberto; Zlobec, Inti; Wartenberg, Martin; Lugli, Alessandro; Gloor, Beat; Perren, Aurel; Karamitopoulou, Evanthia (2015). Expression of E-cadherin repressors SNAIL, ZEB1 and ZEB2 by tumour and stromal cells influences tumour-budding phenotype and suggests heterogeneity of stromal cells in pancreatic cancer. British journal of cancer, 112(12), pp. 1944-1950. Nature Publishing Group 10.1038/bjc.2015.177

Kölzer, Viktor; Zlobec, Inti; Berger, Martin D; Cathomas, Gieri; Dawson, Heather; Dirschmid, Klaus; Hädrich, Marion; Inderbitzin, Daniel; Offner, Felix; Puppa, Giacomo; Seelentag, Walter; Schnüriger, Beat; Tornillo, Luigi; Lugli, Alessandro (2015). Tumor budding in colorectal cancer revisited: results of a multicenter interobserver study. Virchows Archiv, 466(5), pp. 485-493. Springer 10.1007/s00428-015-1740-9

Salhia, Bodour; Trippel, Mafalda; Pfaltz, Katrin; Cihoric, Nikola; Grogg, André; Lädrach, Claudia; Zlobec, Inti; Tapia, Coya (2015). High tumor budding stratifies breast cancer with metastatic properties. Breast cancer research and treatment, 150(2), pp. 363-371. Springer 10.1007/s10549-015-3333-3

Kölzer, Viktor; Dawson, Heather; Andersson, Emilia; Karamitopoulou, Evanthia; Masucci, Giuseppe V; Lugli, Alessandro; Zlobec, Inti (2015). Active immunosurveillance in the tumor microenvironment of colorectal cancer is associated with low frequency tumor budding and improved outcome. Translational Research, 166(2), pp. 207-217. Elsevier 10.1016/j.trsl.2015.02.008

Wartenberg, Martin; Zlobec, Inti; Perren, Aurel; Kölzer, Viktor; Gloor, Beat; Lugli, Alessandro; Karamitopoulou, Evanthia (2015). Accumulation of FOXP3+T-cells in the tumor microenvironment is associated with an epithelial-mesenchymal-transition-type tumor budding phenotype and is an independent prognostic factor in surgically resected pancreatic ductal adenocarcinoma. OncoTarget, 6(6), pp. 4190-4201. Impact Journals LLC

Karamitopoulou, Evanthia; Zlobec, Inti; Kölzer, Viktor; Langer, Rupert; Dawson, Heather; Lugli, Alessandro (2015). Tumour border configuration in colorectal cancer: proposal for an alternative scoring system based on the percentage of infiltrating margin. Histopathology, 67(4), pp. 464-473. Blackwell Scientific Publications 10.1111/his.12665

Galván Hernández, José Alberto; Helbling, Melina; Kölzer, Viktor; Tschan, Mario; Berger, Martin Dave; Hädrich, Marion; Schnüriger, Beat; Karamitopoulou, Evanthia; Dawson, Heather; Inderbitzin, Daniel; Lugli, Alessandro; Zlobec, Inti (2015). TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer. OncoTarget, 6(2), pp. 874-885. Impact Journals LLC 10.18632/oncotarget.2716

Kölzer, Viktor; Herrmann, Pia; Zlobec, Inti; Karamitopoulou, Evanthia; Lugli, Alessandro; Stein, Ulrike (2015). Heterogeneity analysis of Metastasis Associated in Colon Cancer 1 (MACC1) for survival prognosis of colorectal cancer patients: a retrospective cohort study. BMC cancer, 15(160), p. 160. BioMed Central 10.1186/s12885-015-1150-z

Sokol, Lena; Kölzer, Viktor; Rau, Tilman; Karamitopoulou, Evanthia; Zlobec, Inti; Lugli, Alessandro (2015). Loss of tapasin correlates with diminished CD8(+) T-cell immunity and prognosis in colorectal cancer. Journal of translational medicine, 13(279), p. 279. BioMed Central 10.1186/s12967-015-0647-1

Cihoric, Nikola; Tsikkinis, Alexandros; Tapia, Coya; Aebersold, Daniel; Zlobec, Inti; Lössl, Kristina (2015). Dose escalated intensity modulated radiotherapy in the treatment of cervical cancer. Radiation oncology, 10(1), p. 240. BioMed Central 10.1186/s13014-015-0551-0

Vassella, Erik; Galván Hernández, José Alberto; Zlobec, Inti (2015). Tissue Microarray Technology for Molecular Applications: Investigation of Cross-Contamination between Tissue Samples Obtained from the Same Punching Device. Microarrays, 4(2), pp. 188-195. MDPI 10.3390/microarrays4020188

2014

Fleischmann, Achim; Saramäki, Outi R; Zlobec, Inti; Rotzer, Diana; Genitsch Gratwohl, Vera; Seiler, Roland; Visakorpi, Tapio; Thalmann, George (2014). Prevalence and prognostic significance of TMPRSS2-ERG gene fusion in lymph node positive prostate cancers. Prostate, 74(16), pp. 1647-1654. Wiley-Blackwell 10.1002/pros.22882

Dawson, Heather; Grundmann, Sandra; Kölzer, Viktor; Galván Hernández, José Alberto; Kirsch, Richard; Karamitopoulou, Evanthia; Lugli, Alessandro; Inderbitzin, Daniel; Zlobec, Inti (2014). Tyrosine kinase receptor B (TrkB) expression in colorectal cancers highlights anoikis resistance as a survival mechanism of tumour budding cells. Histopathology, 66(5), pp. 715-725. Blackwell Scientific Publications 10.1111/his.12603

Kölzer, Viktor; Zlobec, Inti; Berger, Martin Dave; Cathomas, G; Dawson, Heather; Dirschmid, K; Hädrich, Marion; Inderbitzin, Daniel; Offner, F; Puppa, G; Seelentag, W; Schnüriger, Beat; Tornillo, L; Lugli, Alessandro (6 November 2014). Tumor budding in colorectal cancer: a multicenter inter-observer study on behalf of the Swiss Association of Gastrointestinal Pathology (SAGIP). In: Swiss Society of Pathology 2014. Lausanne, Switzerland.. 06.-08.11.2014.

Karamitopoulou, Evanthia; Thies, Svenja; Zlobec, Inti; Ott, Katja; Feith, Marcus; Slotta-Huspenina, Julia; Lordick, Florian; Becker, Karen; Langer, Rupert (2014). Assessment of tumor regression of esophageal adenocarcinomas after neoadjuvant chemotherapy: comparison of 2 commonly used scoring approaches. The American journal of surgical pathology, 38(11), pp. 1551-1556. Lippincott Williams & Wilkins 10.1097/PAS.0000000000000255

Kölzer, Viktor; Zlobec, Inti; Cathomas, Marionna Myrta; Dirschmid, Klaus; Offner, Felix; Puppa, Giacomo; Tornillo, Luigi; Berger, Martin Dave; Borner, Markus; Dawson, Heather; Hädrich, Marion; Mallaev, Makhmudbek; Schnüriger, Beat; Inderbitzin, Daniel; Lugli, Alessandro (1 September 2014). A multicentre inter-observer study on tumour budding using a 10HPF method in colorectal cancer: a study from the Swiss Association of Gastrointestinal Pathology (SAGIP) (Unpublished). In: European Congress of Pathology 2014. London, UK. 30.08.-03.09.2014.

Helbling, Melina; Lukesch, Anne Carolin; Haimovici, Aladin; Karamitopoulou, Evanthia; Berger, Martin Dave; Hädrich, Marion; Mallaev, Makhmud; Schnüriger, Beat; Kölzer, Viktor; Dawson, Heather; Borner, Markus; Langer, Rupert; Rosenberg, Robert; Nitsche, Ulrich; Inderbitzin, Daniel; Lugli, Alessandro; Tschan, Mario; Zlobec, Inti (2014). Investigation of IL-23 (p19, p40) and IL-23R identifies nuclear expression of IL-23 p19 as a favorable prognostic factor in colorectal cancer: a retrospective multicenter study of 675 patients. OncoTarget, 5(13), pp. 4671-4682. Impact Journals LLC

Cihoric, Nikola; Savic, Mirjana; Schneider, Sabine; Ackermann, I; Bichsel-Naef, Mirjam; Schmid, Ralph; Lardinois, D; Gugger, M; Bubendorf, Lukas; Zlobec, Inti; Tapia, Coya (2014). Prognostic role of FGFR1 amplification in early-stage non-small cell lung cancer. British journal of cancer, 110(12), pp. 2914-2922. Nature Publishing Group 10.1038/bjc.2014.229

Dawson, Heather; Galván Hernández, José Alberto; Helbling, Melina; Müller, Dominique-Elisabeth; Karamitopoulou, Evanthia; Kölzer, Viktor; Economou, Mary; Hammer, Caroline; Lugli, Alessandro; Zlobec, Inti (2014). Possible role of Cdx2 in the serrated pathway of colorectal cancer characterized by BRAF mutation, high-level CpG Island methylator phenotype and mismatch repair-deficiency. International journal of cancer, 134(10), pp. 2342-2351. Wiley-Blackwell 10.1002/ijc.28564

Langer, Rupert; Becker, Karen; Zlobec, Inti; Gertler, Ralf; Sisic, Leila; Büchler, Markus; Lordick, Florian; Slotta-Huspenina, Julia; Weichert, Wilko; Höfler, Heinz; Feith, Marcus; Ott, Katja (2014). A multifactorial histopathologic score for the prediction of prognosis of resected esophageal adenocarcinomas after neoadjuvant chemotherapy. Annals of surgical oncology, 21(3), pp. 915-921. Springer 10.1245/s10434-013-3410-y

Dawson, Heather; Kölzer, Viktor; Karamitopoulou, Evanthia; Economou, Mary; Hammer, Caroline; Müller, Dominique-Elisabeth; Lugli, Alessandro; Zlobec, Inti (2014). The apoptotic and proliferation rate of tumour budding cells in colorectal cancer outlines a heterogeneous population of cells with various impacts on clinical outcome. Histopathology, 64(4), pp. 577-584. Blackwell Scientific Publications 10.1111/his.12294

Zlobec, Inti; Hädrich, Marion; Dawson, Heather; Kölzer, Viktor; Borner, M; Mallaev, M; Schnüriger, Beat; Inderbitzin, Daniel; Lugli, Alessandro (2014). Intratumoural budding (ITB) in preoperative biopsies predicts the presence of lymph node and distant metastases in colon and rectal cancer patients. British journal of cancer, 110(4), pp. 1008-1013. Nature Publishing Group 10.1038/bjc.2013.797

Dawson, Heather; Kölzer, Viktor; Karamitopoulou, Evanthia; Lugli, Alessandro; Zlobec, Inti (February 2014). Loss of Cdx2 Is a Potential Marker of the Serrated Pathway of Colorectal Cancer Characterized by BRAF Mutation, High-Level CpG Island Methylator Phenotype and Mismatch Repair-Deficiency. Modern pathology, 27, 171A-171A. Nature Publishing Group

Dawson, Heather; Kölzer, Viktor; Karamitopoulou, Evanthia; Lugli, Alessandro; Zlobec, Inti (February 2014). Loss of Cdx2 Is a Potential Marker of the Serrated Pathway of Colorectal Cancer Characterized by BRAF Mutation, High-Level CpG Island Methylator Phenotype and Mismatch Repair-Deficiency. Laboratory investigation, 94, 171A-171A. Nature Publishing Group

Galon, Jérôme; Mlecnik, Bernhard; Bindea, Gabriela; Angell, Helen K; Berger, Anne; Lagorce, Christine; Lugli, Alessandro; Zlobec, Inti; Hartmann, Arndt; Bifulco, Carlo; Nagtegaal, Iris D; Palmqvist, Richard; Masucci, Giuseppe V; Botti, Gerardo; Tatangelo, Fabiana; Delrio, Paolo; Maio, Michele; Laghi, Luigi; Grizzi, Fabio; Asslaber, Martin; ... (2014). Towards the introduction of the 'Immunoscore' in the classification of malignant tumours. Journal of pathology, 232(2), pp. 199-209. Wiley 10.1002/path.4287

Sconocchia, Giuseppe; Eppenberger-Castori, Serenella; Zlobec, Inti; Karamitopoulou, Evanthia; Arriga, Roberto; Coppola, Andrea; Caratelli, Sara; Spagnoli, Giulio Cesare; Lauro, Davide; Lugli, Alessandro; Han, Junyi; Iezzi, Giandomenica; Ferrone, Cristina; Ferlosio, Amedeo; Tornillo, Luigi; Droeser, Raoul; Rossi, Piero; Attanasio, Antonio; Ferrone, Soldano and Terracciano, Luigi (2014). HLA class II antigen expression in colorectal carcinoma tumors as a favorable prognostic marker. Neoplasia, 16(1), pp. 31-42. Nature America 10.1593/neo.131568

Kölzer, Viktor H.; Lugli, Alessandro; Dawson, Heather; Hädrich, Marion; Berger, Martin D.; Borner, Markus; Mallaev, Makhmudbek; Galván Hernández, José Alberto; Amsler, Jennifer; Schnüriger, Beat; Zlobec, Inti; Inderbitzin, Daniel (2014). CD8/CD45RO T-cell infiltration in endoscopic biopsies of colorectal cancer predicts nodal metastasis and survival. Journal of translational medicine, 12(81), p. 81. BioMed Central 10.1186/1479-5876-12-81

Zlobec, Inti; Suter, Guido; Perren, Aurel; Lugli, Alessandro (2014). A next-generation tissue microarray (ngTMA) protocol for biomarker studies. Journal of visualized experiments(91), p. 51893. MYJoVE Corporation 10.3791/51893

Kölzer, Viktor; Langer, Rupert; Zlobec, Inti; Lugli, Alessandro (2014). Tumor budding in upper gastrointestinal carcinomas. Frontiers in oncology, 4(216), p. 216. Frontiers Research Foundation 10.3389/fonc.2014.00216

Economou, Mary; Schöni, Liliane; Hammer, Caroline; Galván Hernández, José Alberto; Müller, Dominique-Elisabeth; Zlobec, Inti (2014). Proper paraffin slide storage is crucial for translational research projects involving immunohistochemistry stains. Clinical and translation research, 3(1), p. 4. Springer 10.1186/2001-1326-3-4

2013

Baker, Kristi; Rath, Timo; Flak, Magdalena B.; Arthur, Janelle C.; Chen, Zhangguo; Glickman, Jonathan N.; Zlobec, Inti; Karamitopoulou, Evanthia; Stachler, Matthew D.; Odze, Robert D.; Lencer, Wayne I.; Jobin, Christian; Blumberg, Richard S. (2013). Neonatal Fc receptor expression in dendritic cells mediates protective immunity against colorectal cancer. Immunity, 39(6), pp. 1095-1107. Cell Press 10.1016/j.immuni.2013.11.003

Dawson, Heather; André, Sabine; Karamitopoulou, Evanthia; Zlobec, Inti; Gabius, Hans-Joachim (2013). The growing galectin network in colon cancer and clinical relevance of cytoplasmic galectin-3 reactivity. Anticancer research, 33(8), pp. 3053-3059. International Inst. of Anticancer Research

Obermann, Ellen C.; Savic Prince, Spasenija; Barascud, Audrey; Grilli, Bruno; Herzog, Michelle; Kaup, Daniela; Cathomas, Gieri; Frey Tirri, Brigitte; Zlobec, Inti; Wight, Edward; Bubendorf, Lukas (2013). Prediction of outcome in patients with low-grade squamous intraepithelial lesions by fluorescence in situ hybridization analysis of human papillomavirus, TERC, and MYC. Cancer cytopathology, 121(8), pp. 423-431. Jossey Bass, 10.1002/cncy.21280

Droeser, Raoul A.; Hirt, Christian; Viehl, Carsten T.; Frey, Daniel M.; Nebiker, Christian; Huber, Xaver; Zlobec, Inti; Eppenberger-Castori, Serenella; Tzankov, Alexander; Rosso, Raffaele; Zuber, Markus; Muraro, Manuele Giuseppe; Amicarella, Francesca; Cremonesi, Eleonora; Heberer, Michael; Iezzi, Giandomenica; Lugli, Alessandro; Terracciano, Luigi; Sconocchia, Giuseppe; Oertli, Daniel; ... (2013). Clinical impact of programmed cell death ligand 1 expression in colorectal cancer. European journal of cancer, 49(9), pp. 2233-2242. Elsevier 10.1016/j.ejca.2013.02.015

Zellweger, Tobias; Stürm, Susanne; Rey, Silvia; Zlobec, Inti; Gsponer, Joel R.; Rentsch, Cyrill A.; Terracciano, Luigi M.; Bachmann, Alexander; Bubendorf, Lukas; Ruiz, Christian (2013). Estrogen receptor β expression and androgen receptor phosphorylation correlate with a poor clinical outcome in hormone-naive prostate cancer and are elevated in castration-resistant disease. Endocrine-related cancer, 20(3), pp. 403-413. BioScientifica Ltd. 10.1530/ERC-12-0402

Kölzer, V.; Karamitopoulou, E.; Dawson, Heather; Kondi-Pafiti, A.; Zlobec, I.; Lugli, A. (2013). Geographic analysis of RKIP expression and its clinical relevance in colorectal cancer. British journal of cancer, 108(10), pp. 2088-2096. Nature Publishing Group 10.1038/bjc.2013.197

Zlobec, Inti; Kölzer, Viktor; Dawson, Heather; Perren, Aurel; Lugli, Alessandro (2013). Next-generation tissue microarray (ngTMA) increases the quality of biomarker studies: an example using CD3, CD8, and CD45RO in the tumor microenvironment of six different solid tumor types. Journal of translational medicine, 11(1), p. 104. BioMed Central 10.1186/1479-5876-11-104

Fleischmann, Achim; Seiler, Roland; Zlobec, Inti; Visakorpi, Tapio; Thalmann, George (April 2013). TMPRSS2-ERG Gene Fusion: Frequency and Prognostic Significance in Prostate Cancer Patients with Positive Lymph Nodes. Journal of urology, 189(4), E84-E85. Elsevier

Zlobec, Inti (2013). Novel biomarkers for the prediction of metastasis in colorectal cancer. Expert Opinion on Medical Diagnostics, 7(2), pp. 137-146. Informa Healthcare 10.1517/17530059.2013.753054

Karamitopoulou, Evanthia; Zlobec, I; Born, D; Kondi-Pafiti, A; Lykoudis, P; Mellou, A; Gennatas, K; Gloor, B; Lugli, A (2013). Tumour budding is a strong and independent prognostic factor in pancreatic cancer. European journal of cancer, 49(5), pp. 1032-9. Amsterdam: Elsevier 10.1016/j.ejca.2012.10.022

Karamitopoulou, Evanthia; Zlobec, Inti; Kölzer, Viktor; Kondi-Pafiti, Agathi; Patsouris, Efstratios S; Gennatas, Konstantin; Lugli, Alessandro (2013). Proposal for a 10-high-power-fields scoring method for the assessment of tumor budding in colorectal cancer. Modern pathology, 26(2), pp. 295-301. London: Nature Publishing Group 10.1038/modpathol.2012.155

Maskey, Dipak; Yousefi, Shida; Schmid, Ines; Zlobec, Inti; Perren, Aurel; Friis, Robert; Simon, Hans-Uwe (2013). ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy. Nature communications, 4(1), p. 2130. Nature Publishing Group 10.1038/ncomms3130

Dawson, Heather; Kölzer, Viktor H.; Lukesch, Anne C.; Mallaev, Makhmudbek; Inderbitzin, Daniel; Lugli, Alessandro; Zlobec, Inti (2013). Loss of Cdx2 Expression in Primary Tumors and Lymph Node Metastases is Specific for Mismatch Repair-Deficiency in Colorectal Cancer. Frontiers in oncology, 3, p. 265. Frontiers Research Foundation 10.3389/fonc.2013.00265

Droeser, Raoul A.; Hirt, Christian; Eppenberger-Castori, Serenella; Zlobec, Inti; Viehl, Carsten T.; Frey, Daniel M.; Nebiker, Christian A.; Rosso, Raffaele; Zuber, Markus; Amicarella, Francesca; Iezzi, Giandomenica; Sconocchia, Giuseppe; Heberer, Michael; Lugli, Alessandro; Tornillo, Luigi; Oertli, Daniel; Terracciano, Luigi; Spagnoli, Giulio C. (2013). High myeloperoxidase positive cell infiltration in colorectal cancer is an independent favorable prognostic factor. PLoS ONE, 8(5), e64814. Public Library of Science 10.1371/journal.pone.0064814

Karamitopoulou, Evanthia; Zlobec, Inti; Gloor, Beat; Kondi-Pafiti, Agathi; Lugli, Alessandro; Perren, Aurel (2013). Loss of Raf-1 kinase inhibitor protein (RKIP) is strongly associated with high-grade tumor budding and correlates with an aggressive phenotype in pancreatic ductal adenocarcinoma (PDAC). Journal of translational medicine, 11, p. 311. BioMed Central 10.1186/1479-5876-11-311

Dawson, Heather; Zlobec, Inti; Kölzer, Viktor; Karamitopoulou, Evanthia; Lugli, Alessandro (2013). Expression pattern of TrkB in colorectal cancer supports anoikis-resistance as a survival mechanism for tumor budding cells. Virchows Archiv, 463(2), p. 107. Springer

Karamitopoulou, Evanthia; Zlobec, Inti; Perren, Aurel; Gloor, Beat; Lugli, Alessandro (2013). Increased tumor-budding/CD8+lymphocytes ratio is associated with metastasis and venous invasion in Pancreatic Ductal Adenocarcinoma (PDAC). Virchows Archiv, 463(2), p. 106. Springer

Zlobec, Inti; Kölzer, Viktor; Dawson, Heather; Langer, Rupert; Karamitopoulou, Evanthia; Lugli, Alessandro (2013). Investigation of IL23 (p19, p40) and IL23R highlights nuclear IL23p19 expression as a marker of indolent tumor features and favorable outcome in colorectal cancer patients. Virchows Archiv, 463(2), pp. 139-140. Springer 10.1007/s00428-013-1444-y

Zlobec, Inti; Kölzer, Viktor; Dawson, Heather; Perren, Aurel; Lugli, Alessandro (2013). Next-generation tissue microarray (ngTMA) strengthens pathology biomarker research: An exemplary study of the tumor microenvironment using CD3, CD8, and CD45RO in six different solid tumor types. Virchows Archiv, 463(2), p. 108. Springer

Karamitopoulou, Evanthia; Zlobec, Inti; Gloor, Beat; Lugli, Alessandro; Perren, Aurel (2013). PTEN Loss in the Neoplastic Stroma of Pancreatic Ductal Adenocarcinoma (PDAC) Is a Strong Predictor of Distant Metastasis. Gastroenterology, 144(5) Elsevier

Kölzer, Viktor; Zlobec, Inti; Dawson, Heather; Lugli, Alessandro (2013). The CD8/CD45RO immunoscore in biopsy specimens of colorectal cancer predicts histopathologic features of the matched resection specimen and survival outcome. Virchows Archiv, 463(2), p. 139. Springer

Zlobec, I.; Helbling, M.; Dawson, Heather; Kölzer, V. H.; Diamantis Karamitopoulou, E.; Lugli, A. (2013). Hypermethylation of ZEB2 represents a novel mechanism of colorectal cancer progression and is a highly unfavourable prognostic factor in KRAS wild-type tumors. Virchows Archiv, 463(2), p. 139. Springer

Karamitopoulou, E.; Zlobec, I.; Gloor, B.; Lugli, A.; Kölzer, V. (2013). Loss of PTEN expression in tumor microenvironment correlates with aggressive behaviour and detects synergistic roles of tumor and stromal cells in Pancreatic Ductal Adenocarcinoma (PDAC). Virchows Archiv, 463(2), pp. 290-291. Springer

Trippel, Mafalda; Pfaltz, Katrin; Zlobec, Inti; Tapia, Coya (2013). Tumor Budding Is Significantly Associated with Lymph Node Metastasis in Invasive Ductal Breast Cancer. Laboratory investigation, 93, 73A. Nature Publishing Group

Dawson, Heather; Hädrich, M.; Kölzer, V.; Inderbitzin, D.; Borner, M.; Zlobec, I.; Lugli, A. (2013). Intratumoral Budding (ITB) in Pre-Operative Biopsies: A Strong Indicator of Lymph Node Positivity in Colon and Rectal Cancer Patients. Laboratory investigation, 93(S1), 148A. Nature Publishing Group

Kölzer, V. H.; Dawson, Heather; Karamitopoulou, E.; Lugli, A.; Zlobec, I. (2013). Loss of RKIP Expression in Colorectal Cancer Is Associated with Activation of the NF-kappa B Signaling Pathway and Epithelial-Mesenchymal Transition. Laboratory investigation, 93(S1), 161A-161A. Nature Publishing Group

Fleischmann, Achim; Saramaki, O.; Visakorpi, T.; Zlobec, I.; Thalmann, G. N. (2013). Prostate Cancer Cells with TMPRSS2-ERG Gene Fusion or ERG Overexpression Are Not Selected in the Metastatic Process. Laboratory investigation, 93(S1), 210A. Nature Publishing Group

Feller, S; Zlobec, I.; Burger, Hana; Schäfer, S. C. (2013). Immunohistochemistry Helps To Discriminate between Symplastic Leiomyoma and Leiomyosarcoma of the Uterus. Laboratory investigation, 93(S1), 274A. Nature Publishing Group

Trippel, Mafalda; Pfaltz, Katrin; Zlobec, Inti; Tapia, Coya (2013). Tumor Budding Is Significantly Associated with Lymph Node Metastasis in Invasive Ductal Breast Cancer. Modern pathology, 26, 72A. Nature Publishing Group

Dawson, Heather; Hädrich, M.; Kölzer, V.; Inderbitzin, D.; Borner, M.; Zlobec, I.; Lugli, A. (2013). Intratumoral Budding (ITB) in Pre-Operative Biopsies:A Strong Indicator of Lymph Node Positivity in Colon and Rectal Cancer Patients. Modern pathology, 26, 148A. Nature Publishing Group

Kölzer, V. H.; Dawson, Heather; Karamitopoulou, E.; Lugli, A.; Zlobec, I. (2013). Loss of RKIP Expression in Colorectal Cancer Is Associated with Activation of the NF-kappa B Signaling Pathway and Epithelial-Mesenchymal Transition. Modern pathology, 26(S2), 161A-161A. Nature Publishing Group 10.1038/modpathol.2013.9

Fleischmann, A.; Saramaki, O.; Visakorpi, T.; Zlobec, I.; Thalmann, G. N. (2013). Prostate Cancer Cells with TMPRSS2-ERG Gene Fusion or ERG Overexpression Are Not Selected in the Metastatic Process. Modern pathology, 26(S2), p. 210. Nature Publishing Group

Feller, S.; Zlobec, I.; Burger, Hana; Schäfer, S. C. (2013). Immunohistochemistry Helps To Discriminate between Symplastic Leiomyoma and Leiomyosarcoma of the Uterus. Modern pathology, 26(S2), 274A. Nature Publishing Group

Zlobec, I.; Helbling, M.; Dawson, Heather; Kölzer, V. H.; Karamitopoulou, E.; Lugli, A. (2013). ZEB2 CpG promoter methylation in colorectal cancer is associated with lymph node metastases and invasion in KRAS wild-type patients. Pathologe, 34(6), p. 592. Springer-Medizin-Verlag

Genitsch Gratwohl, Vera; Zlobec, Inti; Thalmann, A. (2013). MUC1 in lymph node metastases predicts survival in advanced prostate cancer. Pathologe, 34(6), p. 596. Springer-Medizin-Verlag

Diamantis-Karamitopoulou, E.; Lugli, A.; Gloor, B.; Perren, A.; Zlobec, I. (2013). Decreased CD8+ lymphocytes/tumor budding ratio is associated with metastasis and venous invasion in pancreatic ductal adenocarcinoma (PDAC). Pathologe, 34(6), p. 601. Springer-Medizin-Verlag

Dawson, Heather; Kölzer, Viktor; Karamitopoulou, Evanthia; Lugli, Alessandro; Zlobec, Inti (2013). TrkB expression in colorectal cancers highlights anoiks-resistance as a possible survival mechanism of tumor budding (EMT-like) cells. Pathologe, 34(6), pp. 602-603. Springer-Medizin-Verlag

Zlobec, I.; Helbling, M.; Karamitopoulou, E.; Dawson, Heather; Kölzer, V. H.; Lugli, A. (2013). CpG promoter hypermethylation of CTNNB1 (B-catenin) and TWIST2 promote a high-grade tumor budding phenotype in colorectal cancer. Pathologe, 34(6), p. 603. Springer-Medizin-Verlag

Kölzer, Viktor; Zlobec, Inti; Dawson, Heather; Lugli, Alessandro (2013). CD8/CD45RO T-cell infiiltration in pre-operative biopsies of colorectal cancer predicts histopathologic features of the matched reseaction specimen and survival outcome. Pathologe, 34(6), p. 603. Springer-Medizin-Verlag

Kölzer, Viktor; Canonica, Katharina; Dawson, Heather; Karamitopoulou, Evanthia; Lugli, Alessandro; Zlobec, Inti (2013). Stromal macrophages closely interact with infiltrating tumor cells in the tumor microenvironemnt of colorectal cancer. Pathologe, 34(6), p. 604. Springer-Medizin-Verlag

Galli, S.; Schürch, C.; Zlobec, I.; Perren, A.; Banz Wälti, Y. (2013). Analysis of CD47 expression in acute myeloid leukemia in a bone marrow tissue microarray. Pathologe, 34(6), p. 608. Springer-Medizin-Verlag

Dawson, Heather; Hädrich, Marion; Kölzer, Viktor; Borner, Markus; Mallaev, M.; Schnüriger, Beat; Inderbitzin, Daniel; Zlobec, Inti; Lugli, Alessandro (2013). Intratumoral budding (ITB) in preoperative biopsies predicts the presence of lymph node and distant metastasis in colon and rectal cancer patients. Pathologe, 34(6), p. 602. Springer-Medizin-Verlag

Dawson, Heather; Helbling, Melina; Karamitopoulou, Evanthia; Kölzer, Viktor; Lugli, Alessandro; Zlobec, Inti (2013). Possible role of Cdx2 in the serrated pathway of colorectal cancer characterized by BRAF mutation, high-level CpG Island methylator phenotype and mismatch repair-deficiency. Pathologe, 34(6), pp. 591-592. Springer-Medizin-Verlag

Karamitopoulou, Evanthia; Zlobec, Inti; Gloor, Beat; Kondi-Pafiti, A.; Lugli, Alessandro; Perren, Aurel (2013). Loss of Raf-1 Kinase Inhibitor Protein (RKIP) promotes Epithelial Mesenchymal Transition (EMT) and correlates with aggressive phenotype in Pancreatic Ductal Adenocarcinoma (PDAC). Virchows Archiv, 463(2), p. 139. Springer

Kölzer, Viktor; Dawson, Heather; Karamitopoulou, Evanthia; Lugli, Alessandro; Zlobec, Inti (2013). Island methylator phenotype and mismatch repair- deficiency. Modern pathology, 24(161A). Nature Publishing Group

2012

Simonetti, Sara; Terracciano, Luigi; Zlobec, Inti; Kilic, Ergin; Stasio, Loredana; Quarto, Maria; Pettinato, Guido; Insabato, Luigi (2012). Immunophenotyping analysis in invasive micropapillary carcinoma of the breast: Role of CD24 and CD44 isoforms expression. Breast, 21(2), pp. 165-70. Amsterdam: Elsevier 10.1016/j.breast.2011.09.004

Droeser, Raoul; Zlobec, Inti; Kilic, Ergin; Güth, Uwe; Heberer, Michael; Spagnoli, Giulio; Oertli, Daniel; Tapia, Coya (2012). Differential pattern and prognostic significance of CD4+, FOXP3+ and IL-17+ tumor infiltrating lymphocytes in ductal and lobular breast cancers. BMC cancer, 12, p. 134. London: BioMed Central 10.1186/1471-2407-12-134

Horcic, Milo; Koelzer, Viktor H; Karamitopoulou, Eva; Terracciano, Luigi; Puppa, Giacomo; Zlobec, Inti; Lugli, Alessandro (2012). Tumor budding score based on 10 high-power fields is a promising basis for a standardized prognostic scoring system in stage II colorectal cancer. Human pathology, 44(5), pp. 697-705. Philadelphia, Pa.: Elsevier 10.1016/j.humpath.2012.07.026

Lugli, A; Karamitopoulou, Eva; Zlobec, I (2012). Tumour budding: a promising parameter in colorectal cancer. British journal of cancer, 106(11), pp. 1713-7. Basingstoke: Nature Publishing Group 10.1038/bjc.2012.127

Piscuoglio, Salvatore; Zlobec, Inti; Pallante, Pierlorenzo; Sepe, Romina; Esposito, Francesco; Zimmermann, Arthur; Diamantis, Ioannis; Terracciano, Luigi; Fusco, Alfredo; Karamitopoulou, Eva (2012). HMGA1 and HMGA2 protein expression correlates with advanced tumour grade and lymph node metastasis in pancreatic adenocarcinoma. Histopathology, 60(3), pp. 397-404. Oxford: Blackwell Scientific Publications 10.1111/j.1365-2559.2011.04121.x

Le Magnen, Clémentine; Bubendorf, Lukas; Ruiz, Christian; Zlobec, Inti; Bachmann, Alexander; Heberer, Michael; Spagnoli, Giulio C.; Wyler, Stephen; Mengus, Chantal (2012). Klf4 transcription factor is expressed in the cytoplasm of prostate cancer cells. European journal of cancer, 49(4), pp. 955-663. Amsterdam: Elsevier 10.1016/j.ejca.2012.09.023

Galon, Jérôme; Pagès, Franck; Marincola, Francesco M.; Angell, Helen K.; Thurin, Magdalena; Lugli, Alessandro; Zlobec, Inti; Berger, Anne; Bifulco, Carlo; Botti, Gerardo; Tatangelo, Fabiana; Britten, Cedrik M.; Kreiter, Sebastian; Chouchane, Lotfi; Delrio, Paolo; Arndt, Hartmann; Asslaber, Martin; Maio, Michele; Masucci, Giuseppe V.; Mihm, Martin; ... (2012). Cancer classification using the Immunoscore: a worldwide task force. Journal of translational medicine, 10, p. 205. London: BioMed Central 10.1186/1479-5876-10-205

Salm, F; Cwiek, P; Ghosal, A; Lucia Buccarello, A; Largey, F; Wotzkow, C; Höland, K; Styp-Rekowska, B; Djonov, V; Zlobec, I; Bodmer, N; Gross, N; Westermann, F; Schäfer, S C; Arcaro, A (2012). RNA interference screening identifies a novel role for autocrine fibroblast growth factor signaling in neuroblastoma chemoresistance. Oncogene, 32(34), pp. 3944-3953. Basingstoke, UK: Nature Publishing Group 10.1038/onc.2012.416

Bihl, Michel P.; Foerster, Anja; Lugli, Alessandro; Zlobec, Inti (2012). Characterization of CDKN2A(p16) methylation and impact in colorectal cancer: systematic analysis using pyrosequencing. Journal of translational medicine, 10, p. 173. London: BioMed Central 10.1186/1479-5876-10-173

Zlobec, Inti; Borner, Markus; Lugli, Alessandro; Inderbitzin, Daniel (2012). Role of intra- and peritumoral budding in the interdisciplinary management of rectal cancer patients. International journal of surgical oncology, 2012, p. 795945. New York, N.Y.: Hindawi 10.1155/2012/795945

Oeggerli, Martin; Tian, Yuemin; Ruiz, Christian; Wijker, Barbara; Sauter, Guido; Obermann, Ellen; Güth, Uwe; Zlobec, Inti; Sausbier, Matthias; Kunzelmann, Karl; Bubendorf, Lukas (2012). Role of KCNMA1 in breast cancer. PLoS ONE, 7(8), e41664. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0041664

Koelzer, Viktor Hendrik; Baker, Kristi; Kassahn, Daniela; Baumhoer, Daniel; Zlobec, Inti (2012). Prognostic impact of β-2-microglobulin expression in colorectal cancers stratified by mismatch repair status. Journal of clinical pathology, 65(11), pp. 996-1002. London: BMJ Publishing Group 10.1136/jclinpath-2012-200742

Zlobec, Inti; Bihl, Michel P; Foerster, Anja; Rufle, Alex; Lugli, Alessandro (2012). The impact of CpG island methylator phenotype and microsatellite instability on tumour budding in colorectal cancer. Histopathology, 61(5), pp. 777-87. Oxford: Blackwell Scientific Publications 10.1111/j.1365-2559.2012.04273.x

Puppa, Giacomo; Senore, Carlo; Sheahan, Kieran; Vieth, Michael; Lugli, Alessandro; Zlobec, Inti; Pecori, Sara; Wang, Lai Mun; Langner, Cord; Mitomi, Hiroyuki; Nakamura, Takatoshi; Watanabe, Masahiko; Ueno, Hideki; Chasle, Jacques; Conley, Stephen A; Herlin, Paulette; Lauwers, Gregory Y; Risio, Mauro (2012). Diagnostic reproducibility of tumour budding in colorectal cancer: a multicentre, multinational study using virtual microscopy. Histopathology, 61(4), pp. 562-575. Oxford: Blackwell Scientific Publications 10.1111/j.1365-2559.2012.04270.x

Zlobec, Inti; Bihl, Michel P; Foerster, Anja; Rufle, Alex; Terracciano, Luigi; Lugli, Alessandro (2012). Stratification and Prognostic Relevance of Jass's Molecular Classification of Colorectal Cancer. Frontiers in oncology, 2, p. 7. Lausanne: Frontiers Research Foundation 10.3389/fonc.2012.00007

Jakscha, Jens; Zlobec, Inti; Storck, Claudio; Obermann, Ellen C; Tornillo, Luigi; Terracciano, Luigi M; Fischer, Claude A (2012). The clinical impact of p16 status in fine-needle aspirates of cervical lymph node metastasis of head and neck squamous cell carcinomas. European archives of oto-rhino-laryngology, 270(2), pp. 661-667. Berlin: Springer 10.1007/s00405-012-2039-y

Giger, Olivier T; Comtesse, Sarah C M; Lugli, Alessandro; Zlobec, Inti; Kurrer, Michael O (2012). Intra-tumoral budding in preoperative biopsy specimens predicts lymph node and distant metastasis in patients with colorectal cancer. Modern pathology, 25(7), pp. 1048-53. London: Nature Publishing Group 10.1038/modpathol.2012.56

Piscuoglio, Salvatore; Lehmann, Frank S; Zlobec, Inti; Tornillo, Luigi; Dietmaier, Wolfgang; Hartmann, Arndt; Wünsch, Peter H; Sessa, Fausto; Rümmele, Petra; Baumhoer, Daniel; Terracciano, Luigi M (2012). Effect of EpCAM, CD44, CD133 and CD166 expression on patient survival in tumours of the ampulla of Vater. Journal of clinical pathology, 65(2), pp. 140-5. London: BMJ Publishing Group 10.1136/jclinpath-2011-200043

Lugli, Alessandro; Hädrich, Marion; Inderbitzin, D; Borner, Markus; Zlobec, Inti (2012). Intratumoral budding is preoperative biopsies predicts local and distant metastasis in colorectal cancer patients. Virchows Archiv, 461(1 (Sup), S11. Springer

Zlobec, Inti; Karamitopoulou, Evanthia; Terracciano, Luigi; Inderbitzin, Daniel; Lugli, Alessandro (2012). Prognostic impact of lymph node ratio outperforms positive lymph nodes and lymph nodes harvested: a time-dependent analysis in mismatch repair-proficient and –deficient colrectal cancers. Virchows Archiv, 461(1), S191. Springer

2011

Lugli, Alessandro; Vlajnic, Tatjana; Giger, Olivier; Karamitopoulou, Eva; Patsouris, Efstratios S; Peros, George; Terracciano, Luigi M; Zlobec, Inti (2011). Intratumoral budding as a potential parameter of tumor progression in mismatch repair-proficient and mismatch repair-deficient colorectal cancer patients. Human pathology, 42(12), pp. 1833-40. Philadelphia, Pa.: Elsevier 10.1016/j.humpath.2011.02.010

Zlobec, Inti; Bihl, Michel; Foerster, Anja; Rufle, Alex; Lugli, Alessandro (2011). Comprehensive analysis of CpG island methylator phenotype (CIMP)-high, -low, and -negative colorectal cancers based on protein marker expression and molecular features. Journal of pathology, 225(3), pp. 336-43. Chichester: Wiley 10.1002/path.2879

Baker, Kristi; Lachapelle, Jonathan; Zlobec, Inti; Bismar, Tarek A; Terracciano, Luigi; Foulkes, William D (2011). Prognostic significance of CD8+ T lymphocytes in breast cancer depends upon both oestrogen receptor status and histological grade. Histopathology, 58(7), pp. 1107-16. Oxford: Blackwell Scientific Publications 10.1111/j.1365-2559.2011.03846.x

Fleischmann, Achim; Rocha, Carla; Saxer-Sekulic, Nikolina; Zlobec, Inti; Sauter, Guido; Thalmann, George N (2011). High CD10 expression in lymph node metastases from surgically treated prostate cancer independently predicts early death. Virchows Archiv, 458(6), pp. 741-8. Berlin: Springer-Verlag 10.1007/s00428-011-1084-z

Zlobec, Inti (2011). Assessing downgrading of locally advanced rectal cancer after chemo-radiotherapy. European journal of cancer, 47(8), pp. 1125-6. Amsterdam: Elsevier 10.1016/j.ejca.2011.02.016

Fleischmann, Achim; Rocha, Carla; Saxer-Sekulic, Nikolina; Zlobec, Inti; Sauter, Guido; Thalmann, George N (2011). High-level cytoplasmic cyclin D1 expression in lymph node metastases from prostate cancer independently predicts early biochemical failure and death in surgically treated patients. Histopathology, 58(5), pp. 781-9. Oxford: Blackwell Scientific Publications 10.1111/j.1365-2559.2011.03800.x

Cindolo, L; Cantile, M; Franco, R; Chiodini, P; Schiavo, G; Forte, I; Zlobec, I; Salzano, L; Botti, G; Gidaro, S; Terracciano, L; Cillo, C (2011). Parallel determination of NeuroD1, chromogranin-A, KI67 and androgen receptor expression in surgically treated prostate cancers. International Braz J Urol - official journal of the Brazilian Society of Urology, 37(1), pp. 57-66. Rio de Janerio: Brazilian Society of Urology 10.1590/S1677-55382011000700008

Hailemariam, Seife; Vosbeck, Jürg; Cathomas, Gieri; Zlobec, Inti; Mattarelli, Gianfranco; Eichenberger, Tobias; Zellweger, Tobias; Bachmann, Alex; Gasser, Thomas C; Bubendorf, Lukas (2011). Can molecular markers stratify the diagnostic value of high-grade prostatic intraepithelial neoplasia? Human pathology, 42(5), pp. 702-9. Philadelphia, Pa.: Elsevier 10.1016/j.humpath.2010.09.006

Lugli, A; Zlobec, I (2011). Gene signatures in colorectal cancer. In: Russo A, Iacobelli S (ed.) Diagnostic, prognostic and therapeutic value of gene signatures (pp. 115-136). Berlin-Heidelberg: Springer