2023
Gander, Thi Thuy Hang; Schläfli, Joëlle; Baumgartner, Johanna; Walthert, Sabrina; Genitsch, Vera; van Geest, Geert; Galván, José A; Cardozo, Carmen; Graham Martinez, Cristina; Grans, Mona; Muth, Sabine; Bruggmann, Rémy; Probst, Hans Christian; Gabay, Cem; Freigang, Stefan
(2023).
Targeted removal of macrophage-secreted interleukin-1 receptor antagonist protects against lethal Candida albicans sepsis.
Immunity, 56(8), 1743-1760.e9.
Cell Press
10.1016/j.immuni.2023.06.023
Bertschi, Nicole L; Steck, Oliver; Luther, Fabian; Bazzini, Cecilia; von Meyenn, Leonhard; Schärli, Stefanie; Vallone, Angela; Felser, Andrea; Keller, Irene; Friedli, Olivier; Freigang, Stefan; Begré, Nadja; Radonjic-Hoesli, Susanne; Lamos, Cristina; Gabutti, Max Philip; Benzaquen, Michael; Laimer, Markus; Simon, Dagmar; Nuoffer, Jean-Marc and Schlapbach, Christoph
(2023).
PPAR-γ regulates the effector function of human T helper 9 cells by promoting glycolysis.
Nature Communications, 14(1), p. 2471.
Springer Nature
10.1038/s41467-023-38233-x
2022
Bertschi, Nicole L; Steck, Oliver; Luther, Fabian; Bazzini, Cecilia; von Meyenn, Leonhard; Felser, Andrea; Keller, Irene; Friedli, Olivier; Freigang, Stefan; Begré, Nadja; Lamos, Cristina; Gabutti, Max Philip; Benzaquen, Michael; Laimer, Markus; Simon, Dagmar; Nuoffer, Jean-Marc; Schlapbach, Christoph
(16 August 2022).
PPAR-γ regulates the effector function of human TH9 cells by promoting glycolysis
(bioRxiv).
Cold Spring Harbor Laboratory
10.1101/2022.08.16.503972
2021
Piattini, Federica; Matsushita, Mai; Muri, Jonathan; Bretscher, Peter; Feng, Xiaogang; Freigang, Stefan; Dalli, Jesmond; Schneider, Christoph; Kopf, Manfred
(2021).
Differential sensitivity of inflammatory macrophages and alternatively activated macrophages to ferroptosis.
European journal of immunology, 51(10), pp. 2417-2429.
Wiley
10.1002/eji.202049114
2020
Leborgne, Nathan G. F.; Taddeo, Adriano; Freigang, Stefan; Benarafa, Charaf
(2020).
Serpinb1a Is Dispensable for the Development and Cytokine Response of Invariant Natural Killer T Cell Subsets.
Frontiers in immunology, 11, p. 562587.
Frontiers Research Foundation
10.3389/fimmu.2020.562587
Saliakoura, Maria; Rossi Sebastiano, Matteo; Pozzato, Chiara; Heidel, Florian H.; Schnöder, Tina M.; Savic Prince, Spasenija; Bubendorf, Lukas; Pinton, Paolo; Schmid, Ralph A.; Baumgartner, Johanna; Freigang, Stefan; Berezowska, Sabina A.; Rimessi, Alessandro; Konstantinidou, Georgia
(2020).
PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia.
Nature cell biology, 22(11), pp. 1382-1395.
Springer Nature
10.1038/s41556-020-00592-8
Jaeger-Ruckstuhl, Carla A.; Hinterbrandner, Magdalena; Höpner, Sabine; Correnti, Colin E; Lüthi, Ursina; Friedli, Olivier; Freigang, Stefan; Al Sayed, Mohamad F; Bührer, Elias D.; Amrein, Michael A.; Schürch, Christian M.; Radpour, Ramin; Riether, Carsten; Ochsenbein, Adrian F.
(2020).
TNIK signaling imprints CD8+ T cell memory formation early after priming.
Nature communications, 11(1), p. 1632.
Nature Publishing Group
10.1038/s41467-020-15413-7
2017
Keller, CW; Loi, M; Ewert, Svenja; Quast, I; Theiler, Romina; Gannagé, M; Münz, C; De Libero, Gennaro; Lünemann, JD; Freigang, Stefan
(2017).
The autophagy machinery restrains iNKT cell activation through CD1D1 internalization.
Autophagy, 13(6), pp. 1025-1036.
Taylor & Francis
10.1080/15548627.2017.1297907
Keller, Christian; Freigang, Stefan; Lünemann, Jan
(2017).
Reciprocal Crosstalk between Dendritic Cells and Natural Killer T Cells: Mechanisms and Therapeutic Potential.
Frontiers in immunology, 8, p. 570.
Frontiers Research Foundation
10.3389/fimmu.2017.00570
Friedli, Olivier; Freigang, Stefan Bernd
(2017).
Cyclopentenone-containing oxidized phospholipids and their isoprostanes as pro-resolving mediators of inflammation.
Biochimica and biophysica acta - molecular and cell biology of lipids, 1862(4), pp. 382-392.
Elsevier
10.1016/j.bbalip.2016.07.006
2016
Zysset, Daniel; Weber, Benjamin; Rihs, Silvia; Brasseit, Jennifer; Freigang, Stefan Bernd; Riether, Carsten; Banz Wälti, Yara; Cerwenka, Adelheid; Simillion, Cedric; Marques-Vidal, Pedro; Ochsenbein, Adrian; Saurer, Leslie; Müller, Christoph
(2016).
TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis.
Nature communications, 7(13151), p. 13151.
Nature Publishing Group
10.1038/ncomms13151
Freigang, Stefan Bernd
(2016).
The regulation of inflammation by oxidized phospholipids.
European journal of immunology, 46(8), pp. 1818-1825.
Wiley-VCH
10.1002/eji.201545676
2015
Egger, Julian; Fischer, Stefan; Bretscher, Peter; Freigang, Stefan; Kopf, Manfred; Carreira, Erick M
(2015).
Total Synthesis of Prostaglandin 15d-PGJ(2) and Investigation of its Effect on the Secretion of IL-6 and IL-12.
Organic letters, 17(17), pp. 4340-4343.
American Chemical Society
10.1021/acs.orglett.5b02181
Bretscher, Peter; Egger, Julian; Shamshiev, Abdijapar; Trötzmüller, Martin; Köfeler, Harald; Carreira, Erick M; Kopf, Manfred; Freigang, Stefan Bernd
(2015).
Phospholipid oxidation generates potent anti-inflammatory lipid mediators that mimic structurally related pro-resolving eicosanoids by activating Nrf2.
EMBO molecular medicine, 7(5), pp. 593-607.
EMBO Press
10.15252/emmm.201404702
Matsushita, Mai; Freigang, Stefan Bernd; Schneider, Christoph; Conrad, Marcus; Bornkamm, Georg W; Kopf, Manfred
(2015).
T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.
The Journal of experimental medicine, 212(4), pp. 555-568.
Rockefeller Univ. Press
10.1084/jem.20140857
2014
Egger, Julian; Bretscher, Peter; Freigang, Stefan Bernd; Kopf, Manfred; Carreira, Erick M
(2014).
Discovery of a highly potent anti-inflammatory epoxyisoprostane-derived lactone.
Journal of the American Chemical Society, 136(50), pp. 17382-17385.
American Chemical Society
10.1021/ja509892u
2013
Freigang, Stefan Bernd; Ampenberger, Franziska; Weiss, Adrienne; Kanneganti, Thirumala-Devi; Iwakura, Yoichiro; Hersberger, Martin; Kopf, Manfred
(2013).
Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis.
Nature immunology, 14(10), pp. 1045-1053.
Nature Publishing Group
10.1038/ni.2704
Freigang, Stefan Bernd; Kain, Lisa; Teyton, Luc
(2013).
Transport and uptake of immunogenic lipids.
Molecular immunology, 55(2), pp. 179-181.
Elsevier
10.1016/j.molimm.2012.10.016
Egger, Julian; Bretscher, Peter; Freigang, Stefan Bernd; Kopf, Manfred; Carreira, Erick M.
(2013).
Synthesis of epoxyisoprostanes: effects in reducing secretion of pro-inflammatory cytokines IL-6 and IL-12.
Angewandte Chemie (International ed.), 52(20), pp. 5382-5385.
Wiley-VCH
10.1002/anie.201300739
Schmitz, Iwana; Schneider, Christoph; Fröhlich, Anja; Frebel, Helge; Christ, Daniel; Leonard, Warren J.; Sparwasser, Tim; Oxenius, Annette; Freigang, Stefan Bernd; Kopf, Manfred
(2013).
IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.
PLoS pathogens, 9(5), e1003362.
Public Library of Science
10.1371/journal.ppat.1003362
