Publikationen

2024

Traidl-Hoffmann, Claudia; Afghani, Jamie; Akdis, Cezmi; Akdis, Mübecel; Aydin, Handan; Bärenfaller, Katja; Behrendt, Heidrun; Bieber, Thomas; Bigliardi, Paul; Bigliardi-Qi, Mei; Bonefeld, Charlotte Menné; Bösch, Stefanie; Brüggen, Marie Charlotte; Diemert, Sebastian; Duchna, Hans-Werner; Fähndrich, Martina; Fehr, Danielle; Fellmann, Marc; Frei, Remo; Garvey, Lena H; ... (2024). Navigating the evolving landscape of atopic dermatitis: Challenges and future opportunities: The 4th Davos declaration. Allergy, 79(10), pp. 2605-2624. Wiley 10.1111/all.16247

2023

Aydin, Sidar; Pareja, Javier; Schallenberg, Vivianne M; Klopstein, Armelle; Gruber, Thomas; Page, Nicolas; Bouillet, Elisa; Blanchard, Nicolas; Liblau, Roland; Körbelin, Jakob; Schwaninger, Markus; Johnson, Aaron J; Schenk, Mirjam; Deutsch, Urban; Merkler, Doron; Engelhardt, Britta (2023). Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown. Nature communications, 14(1), p. 3106. Nature Publishing Group 10.1038/s41467-023-38703-2

von Werdt, Diego; Gungor, Bilgi; Barreto de Albuquerque, Juliana; Gruber, Thomas; Zysset, Daniel; Kwong Chung, Cheong K C; Corrêa-Ferreira, Antonia; Berchtold, Regina; Page, Nicolas; Schenk, Mirjam; Kehrl, John H; Merkler, Doron; Imhof, Beat A; Stein, Jens V; Abe, Jun; Turchinovich, Gleb; Finke, Daniela; Hayday, Adrian C; Corazza, Nadia and Mueller, Christoph (2023). Regulator of G-protein signaling 1 critically supports CD8+ TRM cell-mediated intestinal immunity. Frontiers in immunology, 14, p. 1085895. Frontiers Research Foundation 10.3389/fimmu.2023.1085895

Wallimann, Alexandra; Schenk, Mirjam (2023). IL-32 as a potential biomarker and therapeutic target in skin inflammation. Frontiers in immunology, 14(1264236), p. 1264236. Frontiers Research Foundation 10.3389/fimmu.2023.1264236

2022

Mutisheva, Ivanina; Robatel, Steve; Bäriswyl, Lukas; Schenk, Mirjam (2022). An Innovative Approach to Tissue Processing and Cell Sorting of Fixed Cells for Subsequent Single-Cell RNA Sequencing. International journal of molecular sciences, 23(18) MDPI 10.3390/ijms231810233

Kremenovic, Mirela; Chan, Alfred A; Feng, Bing; Bäriswyl, Lukas; Robatel, Steve; Gruber, Thomas; Tang, Li; Lee, Delphine J; Schenk, Mirjam (2022). BCG hydrogel promotes CTSS-mediated antigen processing and presentation, thereby suppressing metastasis and prolonging survival in melanoma. Journal for immunotherapy of cancer, 10(6), e004133. BioMed Central 10.1136/jitc-2021-004133

Robatel, Steve; Schenk, Mirjam (2022). Current Limitations and Novel Perspectives in Pancreatic Cancer Treatment. Cancers, 14(4) MDPI AG 10.3390/cancers14040985

2021

Gruber, Thomas; Robatel, Steve; Kremenovic, Mirela; Bäriswyl, Lukas; Gertsch, Jürg; Schenk, Mirjam (2021). Cannabinoid Receptor Type-2 in B Cells Is Associated with Tumor Immunity in Melanoma. Cancers, 13(8) MDPI AG 10.3390/cancers13081934

Sadozai, Hassan; Acharjee, Animesh; Eppenberger-Castori, Serenella; Gloor, Beat; Gruber, Thomas; Schenk, Mirjam; Karamitopoulou Diamantis, Evanthia (2021). Distinct Stromal and Immune Features Collectively Contribute to Long-Term Survival in Pancreatic Cancer. Frontiers in immunology, 12(643529), p. 643529. Frontiers Research Foundation 10.3389/fimmu.2021.643529

2020

Kremenovic, M.; Schenk, Mirjam; Lee, D. J. (2020). Clinical and molecular insights into BCG immunotherapy for melanoma. Journal of internal medicine, 288(6), pp. 625-640. Wiley 10.1111/joim.13037

Gruber, Thomas; Kremenovic, Mirela; Sadozai, Hassan; Rombini, Nives; Baeriswyl, Lukas; Maibach, Fabienne; Modlin, Robert L; Gilliet, Michel; von Werdt, Diego; Hunger, Robert E.; Jafari, S. Morteza Seyed; Parisi, Giulia; Abril-Rodriguez, Gabriel; Ribas, Antoni; Schenk, Mirjam (2020). IL-32γ potentiates tumor immunity in melanoma. JCI insight, 5(18) JCI Insight 10.1172/jci.insight.138772

Kremenovic, Mirela; Rombini, Nives; Chan, Alfred A.; Gruber, Thomas; Bäriswyl, Lukas; Lee, Delphine J.; Schenk, Mirjam (2020). Characterization of a Myeloid Activation Signature that Correlates with Survival in Melanoma Patients. Cancers, 12(6), p. 1431. MDPI AG 10.3390/cancers12061431

Bockstahler, Mariella; Fischer, Andrea; Goetzke, Carl Christoph; Neumaier, Hannah Louise; Sauter, Martina; Kespohl, Meike; Müller, Anna-Maria; Meckes, Christin; Salbach, Christian; Schenk, Mirjam; Heuser, Arnd; Landmesser, Ulf; Weiner, January; Meder, Benjamin; Lehmann, Lorenz; Kratzer, Adelheid; Klingel, Karin; Katus, Hugo A.; Kaya, Ziya and Beling, Antje (2020). Heart-Specific Immune Responses in an Animal Model of Autoimmune-Related Myocarditis Mitigated by an Immunoproteasome Inhibitor and Genetic Ablation. Circulation, 141(23), pp. 1885-1902. American Heart Association 10.1161/circulationaha.119.043171

Maibach, Fabienne; Sadozai, Hassan; Jafari, S. Morteza Seyed; Hunger, Robert E.; Schenk, Mirjam (2020). Tumor-Infiltrating Lymphocytes and Their Prognostic Value in Cutaneous Melanoma. Frontiers in immunology, 11(2105), p. 2105. Frontiers Research Foundation 10.3389/fimmu.2020.02105

2018

Keegan, Caroline; Krutzik, Stephan; Schenk, Mirjam; Scumpia, Philip O; Lu, Jing; Pang, Yan Ling Joy; Russell, Brandon S; Lim, Kok Seong; Shell, Scarlet; Prestwich, Erin; Su, Dan; Elashoff, David; Hershberg, Robert M; Bloom, Barry R; Belisle, John T; Fortune, Sarah; Dedon, Peter C; Pellegrini, Matteo; Modlin, Robert L (2018). Transfer RNA Induces IL-12p70 via Synergistic Activation of Pattern Recognition Receptors within a Cell Network. Journal of immunology, 200(9), pp. 3244-3258. American Association of Immunologists 10.4049/jimmunol.1701733

2017

Sadozai, Hassan Ahmed; Gruber, Thomas; Schenk, Mirjam (2017). Induction of effective anti-tumour immunity by targeting dendritic cells in vivo. Madridge Journal of Vaccines, 1(1), e1-e4. Madridge Publishers

Sadozai, Hassan; Gruber, Thomas; Hunger, Robert; Schenk, Mirjam (2017). Recent Successes and Future Directions in Immunotherapy of Cutaneous Melanoma. Frontiers in immunology, 8(1617), p. 1617. Frontiers Research Foundation 10.3389/fimmu.2017.01617

2016

Schenk, Mirjam; Mahapatra, Sebabrata; Le, Phuonganh; Kim, Hee Jin; Choi, Aaron W; Brennan, Patrick J; Belisle, John T; Modlin, Robert L (2016). Human NOD2 Recognizes Structurally Unique Muramyl Dipeptides from Mycobacterium leprae. Infection and immunity, 84(9), pp. 2429-2438. American Society for Microbiology 10.1128/IAI.00334-16

Realegeno, Susan; Kelly-Scumpia, Kindra M; Dang, Angeline Tilly; Lu, Jing; Teles, Rosane; Liu, Philip T; Schenk, Mirjam; Lee, Ernest Y; Schmidt, Nathan W; Wong, Gerard C L; Sarno, Euzenir N; Rea, Thomas H; Ochoa, Maria T; Pellegrini, Matteo; Modlin, Robert L (2016). S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages. PLoS pathogens, 12(6), e1005705. Public Library of Science 10.1371/journal.ppat.1005705

2015

Cappuccio, Antonio; Zollinger, Raphaël; Schenk, Mirjam; Walczak, Aleksandra; Servant, Nicolas; Barillot, Emmanuel; Hupé, Philippe; Modlin, Robert L; Soumelis, Vassili (2015). Combinatorial code governing cellular responses to complex stimuli. Nature communications, 6(6847), p. 6847. Nature Publishing Group 10.1038/ncomms7847

2014

Montoya, Dennis; Inkeles, Megan S; Liu, Phillip T; Realegeno, Susan; Teles, Rosane M B; Vaidya, Poorva; Munoz, Marcos A; Schenk, Mirjam; Swindell, William R; Chun, Rene; Zavala, Kathryn; Hewison, Martin; Adams, John S; Horvath, Steve; Pellegrini, Matteo; Bloom, Barry R; Modlin, Robert L (2014). IL-32 is a molecular marker of a host defense network in human tuberculosis. Science translational medicine, 6(250), 250ra114. American Association for the Advancement of Science 10.1126/scitranslmed.3009546

Schenk, Mirjam; Fabri, Mario; Krutzik, Stephan R; Lee, Delphine J; Vu, David M; Sieling, Peter A; Montoya, Dennis; Liu, Philip T; Modlin, Robert L (2014). Interleukin-1β triggers the differentiation of macrophages with enhanced capacity to present mycobacterial antigen to T cells. Immunology, 141(2), pp. 174-180. Wiley-Blackwell 10.1111/imm.12167

2013

Teles, Rosane M B; Graeber, Thomas G; Krutzik, Stephan R; Montoya, Dennis; Schenk, Mirjam; Lee, Delphine J; Komisopoulou, Evangelia; Kelly-Scumpia, Kindra; Chun, Rene; Iyer, Shankar S; Sarno, Euzenir N; Rea, Thomas H; Hewison, Martin; Adams, John S; Popper, Stephen J; Relman, David A; Stenger, Steffen; Bloom, Barry R; Cheng, Genhong and Modlin, Robert L (2013). Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. Science, 339(6126), pp. 1448-1453. American Association for the Advancement of Science 10.1126/science.1233665

Chung, Andrew W; Sieling, Peter A; Schenk, Mirjam; Teles, Rosane M B; Krutzik, Stephan R; Hsu, Daniel K; Liu, Fu-Tong; Sarno, Euzenir N; Rea, Thomas H; Stenger, Steffen; Modlin, Robert L; Lee, Delphine J (2013). Galectin-3 regulates the innate immune response of human monocytes. Journal of infectious diseases, 207(6), pp. 947-956. Oxford University Press 10.1093/infdis/jis920

2012

Parvatiyar, Kislay; Zhang, Zhiqiang; Teles, Rosane M; Ouyang, Songying; Jiang, Yan; Iyer, Shankar S; Zaver, Shivam A; Schenk, Mirjam; Zeng, Shang; Zhong, Wenwan; Liu, Zhi-Jie; Modlin, Robert L; Liu, Yong-jun; Cheng, Genhong (2012). The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nature immunology, 13(12), pp. 1155-1161. Nature Publishing Group 10.1038/ni.2460

Schenk, Mirjam; Krutzik, Stephan R; Sieling, Peter A; Lee, Delphine J; Teles, Rosane M B; Ochoa, Maria Teresa; Komisopoulou, Evangelia; Sarno, Euzenir N; Rea, Thomas H; Graeber, Thomas G; Kim, Soohyun; Cheng, Genhong; Modlin, Robert L (2012). NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy. Nature medicine, 18(4), pp. 555-563. Nature Publishing Group 10.1038/nm.2650

2011

Fabri, Mario; Stenger, Steffen; Shin, Dong-Min; Yuk, Jae-Min; Liu, Philip T; Realegeno, Susan; Lee, Hye-Mi; Krutzik, Stephan R; Schenk, Mirjam; Sieling, Peter A; Teles, Rosane; Montoya, Dennis; Iyer, Shankar S; Bruns, Heiko; Lewinsohn, David M; Hollis, Bruce W; Hewison, Martin; Adams, John S; Steinmeyer, Andreas; Zügel, Ulrich; ... (2011). Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages. Science translational medicine, 3(104), 104ra102. American Association for the Advancement of Science 10.1126/scitranslmed.3003045

Mudter, Jonas; Yu, Jingling; Zufferey, Christel; Brüstle, Anne; Wirtz, Stefan; Weigmann, Benno; Hoffman, Arthur; Schenk, Mirjam; Galle, Peter R; Lehr, Hans A; Mueller, Christoph; Lohoff, Michael; Neurath, Markus F (2011). IRF4 regulates IL-17A promoter activity and controls RORγt-dependent Th17 colitis in vivo. Inflammatory bowel diseases, 17(6), pp. 1343-1358. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1002/ibd.21476

Weber, Benjamin; Saurer, Leslie; Schenk, Mirjam; Dickgreber, Nina; Mueller, Christoph (2011). CX3CR1 defines functionally distinct intestinal mononuclear phagocyte subsets which maintain their respective functions during homeostatic and inflammatory conditions. European journal of immunology, 41(3), pp. 773-779. Weinheim: Wiley-VCH 10.1002/eji.201040965

2010

Edfeldt, Kristina; Liu, Philip T; Chun, Rene; Fabri, Mario; Schenk, Mirjam; Wheelwright, Matthew; Keegan, Caroline; Krutzik, Stephan R; Adams, John S; Hewison, Martin; Modlin, Robert L (2010). T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 107(52), pp. 22593-22598. National Academy of Sciences NAS 10.1073/pnas.1011624108

2009

Schenk, Mirjam; Belisle, John T; Modlin, Robert L (2009). TLR2 looks at lipoproteins. Immunity, 31(6), pp. 847-849. Cell Press 10.1016/j.immuni.2009.11.008

Montoya, Dennis; Cruz, Daniel; Teles, Rosane M B; Lee, Delphine J; Ochoa, Maria Teresa; Krutzik, Stephan R; Chun, Rene; Schenk, Mirjam; Zhang, Xiaoran; Ferguson, Benjamin G; Burdick, Anne E; Sarno, Euzenir N; Rea, Thomas H; Hewison, Martin; Adams, John S; Cheng, Genhong; Modlin, Robert L (2009). Divergence of macrophage phagocytic and antimicrobial programs in leprosy. Cell host & microbe, 6(4), pp. 343-353. Cell Press 10.1016/j.chom.2009.09.002

Liu, Philip T; Schenk, Mirjam; Walker, Valencia P; Dempsey, Paul W; Kanchanapoomi, Melissa; Wheelwright, Matthew; Vazirnia, Aria; Zhang, Xiaoran; Steinmeyer, Andreas; Zügel, Ulrich; Hollis, Bruce W; Cheng, Genhong; Modlin, Robert L (2009). Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses. PLoS ONE, 4(6), e5810. Public Library of Science 10.1371/journal.pone.0005810

Binda, Elisa; Erhart, Dominik; Schenk, Mirjam; Zufferey, Christel; Renzulli, Pietro; Mueller, Christoph (2009). Quantitative isolation of mouse and human intestinal intraepithelial lymphocytes by elutriation centrifugation. Journal of immunological methods, 344(1), pp. 26-34. Amsterdam: Elsevier 10.1016/j.jim.2009.02.006

2008

Mudter, Jonas; Amoussina, Lioubov; Schenk, Mirjam; Yu, Jingling; Brüstle, Anne; Weigmann, Benno; Atreya, Raja; Wirtz, Stefan; Becker, Christoph; Hoffman, Arthur; Atreya, Imke; Biesterfeld, Stefan; Galle, Peter R; Lehr, Hans A; Rose-John, Stefan; Mueller, Christoph; Lohoff, Michael; Neurath, Markus F (2008). The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6. Journal of clinical investigation, 118(7), pp. 2415-26. Ann Arbor, Mich.: American Society for Clinical Investigation 10.1172/JCI33227

Schenk, Mirjam; Mueller, Christoph (2008). The mucosal immune system at the gastrointestinal barrier. Best practice & research - clinical gastroenterology, 22(3), pp. 391-409. London: Baillière Tindall 10.1016/j.bpg.2007.11.002

2007

Schenk, Mirjam; Mueller, Christoph (2007). Adaptations of intestinal macrophages to an antigen-rich environment. Seminars in immunology, 19(2), pp. 84-93. Philadelphia, Pa.: W.B. Saunders 10.1016/j.smim.2006.09.002

Schenk, Mirjam; Bouchon, Axel; Seibold, Frank; Mueller, Christoph (2007). TREM-1--expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. Journal of clinical investigation, 117(10), pp. 3097-3106. Ann Arbor, Mich.: American Society for Clinical Investigation 10.1172/JCI30602

2005

Schenk, Mirjam; Bouchon, Axel; Birrer, Stefan; Colonna, Marco; Mueller, Christoph (2005). Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine. Journal of immunology, 174(1), pp. 517-524. American Association of Immunologists